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- W2115863721 abstract "It has been recently hypothesized that episodic memory impairment in Alzheimer's disease (AD) most likely involves dysfunction of an integrated network involving the medial temporal lobe, thalamus and posterior cingulate. Thus, investigating the local neuronal traffic alterations along cingulum, a major neuronal white matter (WM) path connecting hippocampus, thalamic and association cortices, has received much attention in AD studies. We developed a new analysis scheme to measure the regional micro structural WM changes along the major cingulum fiber bundle. The local WM alterations along the cingulum bundle are difficult to inspect with the existing analysis methods due to the curved geospatial feature of the cingulum bundle, especially in its posterior and anterior regions. Region-of-interest (ROI) typically measures only one or more prior defined intersections on a WM fiber bundle and encompasses the difficulty to reflect the WM changes in the entire volume of a neuronal connection. It can be subjective and introduce inconsistencies in the placement of ROIs among individual studies. Voxel based morphometric (VBM) does not take enough geospatial information into account and its analysis result is not directly associated with structural connectivity. Our approach is based on diffusion tensor imaging (DTI) tractography and geodesic path mapping, which allows cross-subject evaluation of diffusion measures along a neural path by establishing correspondences through reparameterizing the reconstructed fiber tracts as a function of geodesic distance. The volumetric bilateral major cingulum pathways are represented by using two fiber bundle masks reconstructed from DTI based tractography. Assessment of the technique by comparing 17 amnestic mild cognitive impairment (MCI) participants and 17 age-matched normal controls reveals specific anatomical locations along the left cingulum path with significantly reduced fractional anisotropy value in the MCI subjects. The results show that this analysis technique is able to pinpoint the exact fiber locations with altered diffusion properties and may provide a sensitive approach to determining the integrity of white matter fiber tracts in complex regions of interest in the brain." @default.
- W2115863721 created "2016-06-24" @default.
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- W2115863721 date "2008-07-01" @default.
- W2115863721 modified "2023-09-27" @default.
- W2115863721 title "IC-P2-158: Diffusion tensor analysis for detecting white matter changes in mild cognitive impairment" @default.
- W2115863721 doi "https://doi.org/10.1016/j.jalz.2008.05.2612" @default.
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