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• W2115870569 endingPage "1756" @default.
• W2115870569 startingPage "1728" @default.
• W2115870569 abstract "Plasmodium falciparum is responsible for the most severe form of human malaria. P. vivax, in contrast, is the most widespread malaria parasite with an enormous impact on health and economy, since the infection is characterized by high rates of relapses. Due to the mild course of malaria tertiana and complicated in vitro culturing conditions of P. vivax, most of the research on malaria parasites has focused on P. falciparum so far. The redox metabolism of P. falciparum is a promising target for novel antimalarial drugs, since maintaining a redox equilibrium is of fundamental importance for the parasite. P. falciparum contains a cytosolic glutathione and thioredoxin system, as well as redox systems in the apicoplast and the mitochondrion. In contrast to P. falciparum, little is known about the redox processes in P. vivax so far. This review summarizes the current knowledge of the redox metabolism in malaria parasites and provides a detailed in silico comparison of the known and mostly well characterized redox enzymes from P. falciparum and the largely unknown redox proteins from P. vivax. Known antimalarials at least partially mediating their antiparasitic activity by influencing the redox balance of Plasmodium, including dehydroepiandrosterone, Mannich bases, methylene blue, and naphthoquinones, are discussed. Furthermore, we present novel inhibitors identified via screening of a compound library from the Leibniz Institute for Natural Product Research and Infection Biology, Jena that are active against the redox-related enzymes thioredoxin reductase, glutathione reductase, glutathione-S-transferase, and glucose-6-phosphate dehydrogenase 6- phosphoglucono- lactonase from P. falciparum. Keywords: Antimalarials, disulfide reductase inhibitors, glutathione, malaria, oxidative stress, Plasmodium vivax, redox metabolism, thioredoxin." @default.
• W2115870569 created "2016-06-24" @default.
• W2115870569 creator A5032304709 @default.
• W2115870569 creator A5050210012 @default.
• W2115870569 creator A5056324322 @default.
• W2115870569 creator A5063843251 @default.
• W2115870569 date "2014-04-01" @default.
• W2115870569 modified "2023-09-26" @default.
• W2115870569 title "The Redox Systems of Plasmodium falciparum and Plasmodium vivax: Comparison, In silico Analyses and Inhibitor Studies" @default.
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