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- W2115890658 abstract "We augmented existing computationally predicted and experimentally determined interactions with evolutionarily conserved interactions between proteins of the malaria parasite, P. falciparum, and the human host. In a validation step, we found that conserved interacting host-parasite protein pairs were specifically expressed in host tissues where both the parasite and host proteins are known to be active. We compared host-parasite interactions with experimentally verified interactions between human host proteins and a very different pathogen, HIV-1. Both pathogens were found to use their protein repertoire in a combinatorial manner, providing a broad connection to host cellular processes. Specifically, the two biologically distinct pathogens predominately target central proteins to take control of a human host cell, effectively reaching into diversified cellular host cellular functions. Interacting signaling pathways and a small set of regulatory and signaling proteins were prime targets of both pathogens, suggesting remarkably similar patterns of host-pathogen interactions despite the vast biological differences of both pathogens. Such an identification of shared molecular strategies by the virus HIV-1 and the eukaryotic intracellular pathogen P. falciparum may allow us to illuminate new avenues of disease intervention." @default.
- W2115890658 created "2016-06-24" @default.
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- W2115890658 date "2011-10-01" @default.
- W2115890658 modified "2023-10-15" @default.
- W2115890658 title "Shared Molecular Strategies of the Malaria Parasite P. falciparum and the Human Virus HIV-1" @default.
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- W2115890658 doi "https://doi.org/10.1074/mcp.m111.009035" @default.
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