FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115898123> ?p ?o ?g. }

• W2115898123 endingPage "2791" @default.
• W2115898123 startingPage "2785" @default.
• W2115898123 abstract "Leishmania braziliensis (isolate 2903) was naturally resistant to ketoconazole or the bis-triazole D0870, inhibitors of sterol C-14 demethylase, which produced only moderate effects on the proliferation of promastigotes at 10 microM. In contrast, Leishmania mexicana (isolate NR) was extremely susceptible to the azoles, as complete growth arrest and cell lysis were induced by incubation of the parasites with 0.05 microM concentrations of the drugs for 72 h. The opposite response was observed with terbinafine, an inhibitor of squalene epoxidase: L. braziliensis 2903 was three times more susceptible to the drug than L. mexicana NR (MICs of 5 and 15 microM, respectively). However, when the L. braziliensis stock was grown in the presence of 1 microM terbinafine, which by itself produced only marginal (< 10%) effects on growth, it became highly susceptible to the azoles, with an MIC of 0.03 microM. Analysis of cellular free sterols by high-resolution capillary gas chromatography coupled to mass spectrometry showed that 14-methyl sterols can support normal growth of L. braziliensis 2903 but not of L. mexicana NR. On the other hand, the higher susceptibility of the L. braziliensis isolate to terbinafine was correlated with a massive accumulation of squalene in the presence of the allylamine while no significant effects on L. mexicana sterol composition were observed at drug concentrations up to 1 microM. Thus, the > 300-fold increase in the susceptibility of L. braziliensis promastigotes to azoles in the presence of terbinafine was attributed to the combined effect of squalene and the methylated sterol precursors on the physical properties of the cell's membranes, leading to the loss of cell viability. Combination therapy with azoles and terbinafine in the treatment of human L. braziliensis infections deserves further study." @default.
• W2115898123 created "2016-06-24" @default.
• W2115898123 creator A5005864207 @default.
• W2115898123 creator A5014684114 @default.
• W2115898123 creator A5063174004 @default.
• W2115898123 creator A5076829138 @default.
• W2115898123 creator A5014312546 @default.
• W2115898123 date "1996-12-01" @default.
• W2115898123 modified "2023-10-10" @default.
• W2115898123 title "Naturally azole-resistant Leishmania braziliensis promastigotes are rendered susceptible in the presence of terbinafine: comparative study with azole-susceptible Leishmania mexicana promastigotes" @default.
• W2115898123 cites W116018813 @default.
• W2115898123 cites W1489042738 @default.
• W2115898123 cites W1835042769 @default.
• W2115898123 cites W1963605907 @default.
• W2115898123 cites W1967206933 @default.
• W2115898123 cites W1967711052 @default.
• W2115898123 cites W1969900206 @default.
• W2115898123 cites W1975945034 @default.
• W2115898123 cites W1978045097 @default.
• W2115898123 cites W1980326221 @default.
• W2115898123 cites W1981845645 @default.
• W2115898123 cites W1983584866 @default.
• W2115898123 cites W1985192732 @default.
• W2115898123 cites W1985868031 @default.
• W2115898123 cites W1993632452 @default.
• W2115898123 cites W2005875868 @default.
• W2115898123 cites W2012676222 @default.
• W2115898123 cites W2026000152 @default.
• W2115898123 cites W2028649651 @default.
• W2115898123 cites W2041375888 @default.
• W2115898123 cites W2042121126 @default.
• W2115898123 cites W2044217811 @default.
• W2115898123 cites W2044576316 @default.
• W2115898123 cites W2045184811 @default.
• W2115898123 cites W2051143095 @default.
• W2115898123 cites W2051621171 @default.
• W2115898123 cites W2055714119 @default.
• W2115898123 cites W2057228350 @default.
• W2115898123 cites W2058339026 @default.
• W2115898123 cites W2060986287 @default.
• W2115898123 cites W2064796591 @default.
• W2115898123 cites W2072737334 @default.
• W2115898123 cites W2072986916 @default.
• W2115898123 cites W2078173288 @default.
• W2115898123 cites W2083678132 @default.
• W2115898123 cites W2091486221 @default.
• W2115898123 cites W2095393416 @default.
• W2115898123 cites W2113456505 @default.
• W2115898123 cites W2123264979 @default.
• W2115898123 cites W2130547867 @default.
• W2115898123 cites W2135476804 @default.
• W2115898123 cites W2147032776 @default.
• W2115898123 cites W2157935239 @default.
• W2115898123 cites W2203917792 @default.
• W2115898123 cites W2292441262 @default.
• W2115898123 cites W2398121506 @default.
• W2115898123 cites W53557829 @default.
• W2115898123 cites W2295835646 @default.
• W2115898123 doi "https://doi.org/10.1128/aac.40.12.2785" @default.
• W2115898123 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/163622" @default.
• W2115898123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9124841" @default.
• W2115898123 hasPublicationYear "1996" @default.
• W2115898123 type Work @default.
• W2115898123 sameAs 2115898123 @default.
• W2115898123 citedByCount "53" @default.
• W2115898123 countsByYear W21158981232012 @default.
• W2115898123 countsByYear W21158981232013 @default.
• W2115898123 countsByYear W21158981232014 @default.
• W2115898123 countsByYear W21158981232015 @default.
• W2115898123 countsByYear W21158981232016 @default.
• W2115898123 countsByYear W21158981232017 @default.
• W2115898123 countsByYear W21158981232021 @default.
• W2115898123 countsByYear W21158981232022 @default.
• W2115898123 crossrefType "journal-article" @default.
• W2115898123 hasAuthorship W2115898123A5005864207 @default.
• W2115898123 hasAuthorship W2115898123A5014312546 @default.
• W2115898123 hasAuthorship W2115898123A5014684114 @default.
• W2115898123 hasAuthorship W2115898123A5063174004 @default.
• W2115898123 hasAuthorship W2115898123A5076829138 @default.
• W2115898123 hasBestOaLocation W21158981231 @default.
• W2115898123 hasConcept C136764020 @default.
• W2115898123 hasConcept C181199279 @default.
• W2115898123 hasConcept C203014093 @default.
• W2115898123 hasConcept C2776555147 @default.
• W2115898123 hasConcept C2776703722 @default.
• W2115898123 hasConcept C2777071850 @default.
• W2115898123 hasConcept C2777735729 @default.
• W2115898123 hasConcept C2778163477 @default.
• W2115898123 hasConcept C2778236110 @default.
• W2115898123 hasConcept C2778702967 @default.
• W2115898123 hasConcept C2778718757 @default.
• W2115898123 hasConcept C2779548794 @default.
• W2115898123 hasConcept C2780315139 @default.
• W2115898123 hasConcept C2781092759 @default.
• W2115898123 hasConcept C2781371782 @default.
• W2115898123 hasConcept C41008148 @default.
• W2115898123 hasConcept C553450214 @default.
• W2115898123 hasConcept C55493867 @default.

• next