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- W2115910368 abstract "RNA molecules are versatile biomaterials that act not only as DNA ‐like genetic materials but also have diverse functions in regulation of cellular biosystems. RNA is capable of regulating gene expression by sequence‐specific hybridization. This feature allows the design of RNA ‐based artificial gene regulators (riboregulators). RNA can also build complex two‐dimensional ( 2D ) and 3D nanostructures, which afford protein‐like functions and make RNA an attractive material for nanobiotechnology. RNA tectonics is a methodology in RNA nanobiotechnology for the design and construction of RNA nanostructures/nanoobjects through controlled self‐assembly of modular RNA units ( tectoRNAs ). RNA nanostructures designed according to the concept of RNA tectonics are also attractive as tools in synthetic biology, but in vivo RNA tectonics is still in the early stages. This review presents a summary of the achievements of RNA tectonics and its related researches in vitro , and also introduces recent developments that facilitated the use of RNA nanostructures in bacterial cells. WIREs RNA 2013, 4:651–664. doi: 10.1002/wrna.1185 This article is categorized under: RNA Structure and Dynamics > RNA Structure, Dynamics, and Chemistry RNA Methods > RNA Analyses In Vitro and In Silico" @default.
- W2115910368 created "2016-06-24" @default.
- W2115910368 creator A5012231366 @default.
- W2115910368 creator A5030831341 @default.
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- W2115910368 date "2013-07-08" @default.
- W2115910368 modified "2023-09-29" @default.
- W2115910368 title "RNA Tectonics (tectoRNA) for RNA nanostructure design and its application in synthetic biology" @default.
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- W2115910368 doi "https://doi.org/10.1002/wrna.1185" @default.
- W2115910368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23836522" @default.
- W2115910368 hasPublicationYear "2013" @default.
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