Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115913885> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2115913885 endingPage "745" @default.
- W2115913885 startingPage "737" @default.
- W2115913885 abstract "Abstract In the present open-label, short-term study the effects of policosanol in the treatment of patients with type II hypercholesterolemia and high global coronary risk were investigated. After dietary stabilization during a 5-week baseline period, 54 patients were instructed to take policosanol 20 mg once daily with the evening meal for 8 weeks. All of the patients had a family history of death caused by coronary artery disease and one or more personal coronary risk factors other than hypercholesterolemia (eg, hypertension [64,8%], previous coronary events [40.7%], smoking [31.5%], and obesity [18.5%]). Fifty percent of the patients were postmenopausal women and 24.1% were men aged >45 years. In addition, 25 patients (46.3%) showed severe hypercholesterolemia (total cholesterol >7.8 mmol/L). At 8 weeks, policosanol significantly reduced low-density lipoprotein cholesterol (LDL-C) (22.6%) and total cholesterol (16.9%) and significantly increased high-density lipoprotein cholesterol (HDL-C) (20.0%). Consequently, the ratios of total cholesterol:HDL-C and LDL-C:HDL-C decreased significantly (25.5% and 29.9%, respectively). Triglycerides did not change significantly after treatment with policosanol. Forty patients (80%) of the 50 patients who completed the study had >15% reductions in LDL-C levels after 8 weeks of therapy. The treatment was well tolerated. No drug-related clinical or blood biochemical adverse effects were detected. Four patients reported mild adverse effects, but none of the patients withdrew from the study because of such effects. The present study suggests that policosanol 20 mg once daily in patients with type II hypercholesterolemia and high global coronary risk was safe, well tolerated, and effective in lowering cholesterol. This highest recommended dosage needs to be studied further among a larger population for a longer duration to make recommendations for lowering cholesterol and to judge the effects of policosanol on the outcomes of patients with global coronary risk." @default.
- W2115913885 created "2016-06-24" @default.
- W2115913885 creator A5004583485 @default.
- W2115913885 creator A5008007519 @default.
- W2115913885 creator A5070801357 @default.
- W2115913885 creator A5077245743 @default.
- W2115913885 creator A5084424565 @default.
- W2115913885 creator A5089085411 @default.
- W2115913885 date "1998-10-01" @default.
- W2115913885 modified "2023-10-18" @default.
- W2115913885 title "Open-label study of the efficacy, safety, and tolerability of policosanol in patients with high global coronary risk" @default.
- W2115913885 cites W1541421734 @default.
- W2115913885 cites W1971474046 @default.
- W2115913885 cites W1973421436 @default.
- W2115913885 cites W1983938422 @default.
- W2115913885 cites W1989413919 @default.
- W2115913885 cites W1994415079 @default.
- W2115913885 cites W1998284346 @default.
- W2115913885 cites W2000228832 @default.
- W2115913885 cites W2015266591 @default.
- W2115913885 cites W2040567808 @default.
- W2115913885 cites W2043296622 @default.
- W2115913885 cites W2046206561 @default.
- W2115913885 cites W2046634803 @default.
- W2115913885 cites W2048527004 @default.
- W2115913885 cites W2049098782 @default.
- W2115913885 cites W2063265885 @default.
- W2115913885 cites W2064347822 @default.
- W2115913885 cites W2069432646 @default.
- W2115913885 cites W2069575574 @default.
- W2115913885 cites W2070613877 @default.
- W2115913885 cites W2075391376 @default.
- W2115913885 cites W2078705150 @default.
- W2115913885 cites W2081394180 @default.
- W2115913885 cites W2091535932 @default.
- W2115913885 cites W2105525299 @default.
- W2115913885 cites W2116404316 @default.
- W2115913885 cites W2118310760 @default.
- W2115913885 cites W2140318545 @default.
- W2115913885 cites W2155598961 @default.
- W2115913885 cites W2341665659 @default.
- W2115913885 cites W4248021162 @default.
- W2115913885 cites W4254363271 @default.
- W2115913885 doi "https://doi.org/10.1016/s0011-393x(98)85033-9" @default.
- W2115913885 hasPublicationYear "1998" @default.
- W2115913885 type Work @default.
- W2115913885 sameAs 2115913885 @default.
- W2115913885 citedByCount "12" @default.
- W2115913885 countsByYear W21159138852019 @default.
- W2115913885 crossrefType "journal-article" @default.
- W2115913885 hasAuthorship W2115913885A5004583485 @default.
- W2115913885 hasAuthorship W2115913885A5008007519 @default.
- W2115913885 hasAuthorship W2115913885A5070801357 @default.
- W2115913885 hasAuthorship W2115913885A5077245743 @default.
- W2115913885 hasAuthorship W2115913885A5084424565 @default.
- W2115913885 hasAuthorship W2115913885A5089085411 @default.
- W2115913885 hasConcept C126322002 @default.
- W2115913885 hasConcept C197934379 @default.
- W2115913885 hasConcept C2778375690 @default.
- W2115913885 hasConcept C3018359032 @default.
- W2115913885 hasConcept C71924100 @default.
- W2115913885 hasConcept C98274493 @default.
- W2115913885 hasConceptScore W2115913885C126322002 @default.
- W2115913885 hasConceptScore W2115913885C197934379 @default.
- W2115913885 hasConceptScore W2115913885C2778375690 @default.
- W2115913885 hasConceptScore W2115913885C3018359032 @default.
- W2115913885 hasConceptScore W2115913885C71924100 @default.
- W2115913885 hasConceptScore W2115913885C98274493 @default.
- W2115913885 hasIssue "10" @default.
- W2115913885 hasLocation W21159138851 @default.
- W2115913885 hasOpenAccess W2115913885 @default.
- W2115913885 hasPrimaryLocation W21159138851 @default.
- W2115913885 hasRelatedWork W1736016875 @default.
- W2115913885 hasRelatedWork W192509002 @default.
- W2115913885 hasRelatedWork W1994915643 @default.
- W2115913885 hasRelatedWork W2037576960 @default.
- W2115913885 hasRelatedWork W2409130183 @default.
- W2115913885 hasRelatedWork W2922882148 @default.
- W2115913885 hasRelatedWork W2997014956 @default.
- W2115913885 hasRelatedWork W3111488754 @default.
- W2115913885 hasRelatedWork W4253098345 @default.
- W2115913885 hasRelatedWork W4319063555 @default.
- W2115913885 hasVolume "59" @default.
- W2115913885 isParatext "false" @default.
- W2115913885 isRetracted "false" @default.
- W2115913885 magId "2115913885" @default.
- W2115913885 workType "article" @default.