FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2115920211> ?p ?o ?g. }

• W2115920211 endingPage "10150" @default.
• W2115920211 startingPage "10144" @default.
• W2115920211 abstract "The development of prostate carcinoma is associated with alterations in fatty acid metabolism. α-Methylacyl-CoA racemase (AMACR) is a peroxisomal and mitochondrial enzyme that catalyses interconversion between the (S)/(R)-isomers of a range of α-methylacyl-CoA thioesters. AMACR is involved in the β-oxidation of the dietary branched-chain fatty acids and bile acid intermediates. It is highly expressed in prostate (more than 95 %), colon (92 %), and breast cancers (44 %) but not in the respective normal or hyperplastic tissues. Thus, targeting of AMACR could be a new strategy for molecular imaging and therapy of prostate and some other cancers. Unlabeled 2-methylenacyl-CoA thioesters (12 a-c) were designed as AMACR binding ligands. The thioesters were tested for their ability to inhibit the AMACR-mediated epimerization of (25R)-THC-CoA and were found to be strong AMACR inhibitors. Radioiodinated (E)-(131) I-13-iodo-2-methylentridec-12-enoic acid ((131) I-7 c) demonstrated preferential retention in AMACR-positive prostate tumor cells (LNCaP, LNCaP C4-2wt and DU145) compared with both AMACR-knockout LNCaP C4-2 AMACR-siRNA and benign BPH1 prostate cell lines. A significant protein-bound radioactive fraction with main bands at 47 (sum of molecular weights of AMACR plus 12 c), 70, and 75 kDa was detected in LNCaP C4-2 wt cells. In contrast, only negligible amounts of protein-bound radioactivity were found in LNCaP C4-2 AMACR-siRNA cells." @default.
• W2115920211 created "2016-06-24" @default.
• W2115920211 creator A5012029724 @default.
• W2115920211 creator A5022566497 @default.
• W2115920211 creator A5030234706 @default.
• W2115920211 creator A5048598262 @default.
• W2115920211 creator A5053697167 @default.
• W2115920211 creator A5058325456 @default.
• W2115920211 creator A5064614134 @default.
• W2115920211 creator A5071282394 @default.
• W2115920211 creator A5073041193 @default.
• W2115920211 creator A5086561914 @default.
• W2115920211 creator A5089475052 @default.
• W2115920211 date "2011-08-02" @default.
• W2115920211 modified "2023-10-02" @default.
• W2115920211 title "New Molecular Markers for Prostate Tumor Imaging: A Study on 2-Methylene Substituted Fatty Acids as New AMACR Inhibitors" @default.
• W2115920211 cites W1508323706 @default.
• W2115920211 cites W1872235201 @default.
• W2115920211 cites W1977429096 @default.
• W2115920211 cites W1977809420 @default.
• W2115920211 cites W1995620315 @default.
• W2115920211 cites W1999109251 @default.
• W2115920211 cites W2024400005 @default.
• W2115920211 cites W2029376999 @default.
• W2115920211 cites W2035936829 @default.
• W2115920211 cites W2038743280 @default.
• W2115920211 cites W2045171105 @default.
• W2115920211 cites W2060768796 @default.
• W2115920211 cites W2070168741 @default.
• W2115920211 cites W2073335166 @default.
• W2115920211 cites W2078927874 @default.
• W2115920211 cites W2087306576 @default.
• W2115920211 cites W2088818502 @default.
• W2115920211 cites W2091461735 @default.
• W2115920211 cites W2095128237 @default.
• W2115920211 cites W2101995865 @default.
• W2115920211 cites W2116205530 @default.
• W2115920211 cites W2141371533 @default.
• W2115920211 cites W2142042921 @default.
• W2115920211 cites W2152269636 @default.
• W2115920211 cites W2161137325 @default.
• W2115920211 cites W2262693112 @default.
• W2115920211 cites W2886024925 @default.
• W2115920211 cites W2951476489 @default.
• W2115920211 cites W4231809167 @default.
• W2115920211 cites W4243267307 @default.
• W2115920211 cites W4365787468 @default.
• W2115920211 cites W4379614214 @default.
• W2115920211 cites W67657183 @default.
• W2115920211 doi "https://doi.org/10.1002/chem.201003176" @default.
• W2115920211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21812041" @default.
• W2115920211 hasPublicationYear "2011" @default.
• W2115920211 type Work @default.
• W2115920211 sameAs 2115920211 @default.
• W2115920211 citedByCount "19" @default.
• W2115920211 countsByYear W21159202112012 @default.
• W2115920211 countsByYear W21159202112013 @default.
• W2115920211 countsByYear W21159202112014 @default.
• W2115920211 countsByYear W21159202112015 @default.
• W2115920211 countsByYear W21159202112016 @default.
• W2115920211 countsByYear W21159202112017 @default.
• W2115920211 countsByYear W21159202112018 @default.
• W2115920211 countsByYear W21159202112019 @default.
• W2115920211 countsByYear W21159202112020 @default.
• W2115920211 countsByYear W21159202112021 @default.
• W2115920211 countsByYear W21159202112023 @default.
• W2115920211 crossrefType "journal-article" @default.
• W2115920211 hasAuthorship W2115920211A5012029724 @default.
• W2115920211 hasAuthorship W2115920211A5022566497 @default.
• W2115920211 hasAuthorship W2115920211A5030234706 @default.
• W2115920211 hasAuthorship W2115920211A5048598262 @default.
• W2115920211 hasAuthorship W2115920211A5053697167 @default.
• W2115920211 hasAuthorship W2115920211A5058325456 @default.
• W2115920211 hasAuthorship W2115920211A5064614134 @default.
• W2115920211 hasAuthorship W2115920211A5071282394 @default.
• W2115920211 hasAuthorship W2115920211A5073041193 @default.
• W2115920211 hasAuthorship W2115920211A5086561914 @default.
• W2115920211 hasAuthorship W2115920211A5089475052 @default.
• W2115920211 hasConcept C121608353 @default.
• W2115920211 hasConcept C126322002 @default.
• W2115920211 hasConcept C185592680 @default.
• W2115920211 hasConcept C2776235491 @default.
• W2115920211 hasConcept C2776438761 @default.
• W2115920211 hasConcept C2779723316 @default.
• W2115920211 hasConcept C2780192828 @default.
• W2115920211 hasConcept C502942594 @default.
• W2115920211 hasConcept C55493867 @default.
• W2115920211 hasConcept C71924100 @default.
• W2115920211 hasConceptScore W2115920211C121608353 @default.
• W2115920211 hasConceptScore W2115920211C126322002 @default.
• W2115920211 hasConceptScore W2115920211C185592680 @default.
• W2115920211 hasConceptScore W2115920211C2776235491 @default.
• W2115920211 hasConceptScore W2115920211C2776438761 @default.
• W2115920211 hasConceptScore W2115920211C2779723316 @default.
• W2115920211 hasConceptScore W2115920211C2780192828 @default.
• W2115920211 hasConceptScore W2115920211C502942594 @default.
• W2115920211 hasConceptScore W2115920211C55493867 @default.
• W2115920211 hasConceptScore W2115920211C71924100 @default.

• next