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- W2115933302 abstract "Focal areas of increased uptake of [3H]cholesterol in vivo by the macroscopically normal young pig aorta have been identified by their ability to accumulate the protein-binding azo dye, Evans blue. The distribution of labelled cholesterol across the aortic wall in areas of dye uptake (blue areas) and no dye uptake (white areas) was determined at intervals from 10 min to 24 h after the injection of label. Labelled free cholesterol represented most of the label in the aorta. It was distributed non-uniformly across the aortic wall, with most label concentrated in the intima and inner media. Labelled cholesterol ester represented only a small proportion of the aortic label and was distributed evenly through the vessel wall. Free cholesterol activity and free cholesterol specific activity were greater in blue areas than in white areas. These differences were confined to the intima and inner media and also the adventitia. Free cholesterol distribution and DNA content and distribution across the aortic wall were similar in blue and white areas. It is suggested that the increased focal uptake of labelled free cholesterol by blue areas reflects a higher free cholesterol turnover in these areas, and that labelled plasma cholesterol enters the pig aorta mainly through the intima in vivo." @default.
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- W2115933302 date "1972-11-01" @default.
- W2115933302 modified "2023-09-23" @default.
- W2115933302 title "Focal [3h]cholesterol uptake in the pig aorta Part 2. Distribution of [3h]cholesterol across the aortic wall in areas of high and low uptake in vivo" @default.
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- W2115933302 doi "https://doi.org/10.1016/0021-9150(72)90085-8" @default.
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