FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116006487> ?p ?o ?g. }

• W2116006487 endingPage "1030" @default.
• W2116006487 startingPage "1024" @default.
• W2116006487 abstract "We studied the effect of leukotriene D₄ (LTD₄) on a human bronchial epithelial cell line (16HBE) overexpressing the cysteinyl leukotriene (CysLT) ₁ receptor (HBECysLT₁R), looking at the associated signal transduction mechanisms as well as at effects on inflammatory cell adhesion. The results obtained showed that LTD₄ increases the phosphorylation of extracellular signal-regulated protein kinase (ERK) 1/2 and of the signal transducer and activator of transcription 1 (STAT-1) in serine 727 (STAT-1Ser727), resulting in increased eosinophil adhesion to HBECysLT₁R, associated with enhanced surface expression of intercellular adhesion molecule (ICAM) 1. Pretreatment with a CysLT₁R-selective antagonist or with a selective inhibitor of protein kinase C (PKC) or with a selective inhibitor of the mitogen-activated protein kinase kinase (MEK) successfully suppressed both LTD₄-induced STAT-1Ser727 phosphorylation and the associated increase in eosinophil adhesion. The use of the MEK inhibitor and of the selective CysLT₁R antagonist in electrophoretic mobility shift assay experiments showed that LTD₄ promotes the nuclear translocation of STAT-1 through the activation of ERK1/2 pathway. The key role of STAT-1 in leukotriene D₄ transduction signaling was confirmed by RNA interference experiments, where silencing of STAT-1 expression abolished the effect of leukotriene D₄ on eosinophil adhesion. In conclusion, for the first time, we provide evidence of the involvement of STAT-1 in the signal transduction mechanism of the CysLT₁ receptor; phosphorylation of STAT-1, through PKC and ERK1/2 activation, causes enhanced ICAM-1 surface expression and eosinophil adhesion. Effective CysLT₁R antagonism may therefore contribute to the control of the chronic inflammatory condition that characterizes human airways in asthma." @default.
• W2116006487 created "2016-06-24" @default.
• W2116006487 creator A5002911229 @default.
• W2116006487 creator A5003759113 @default.
• W2116006487 creator A5025888123 @default.
• W2116006487 creator A5029667558 @default.
• W2116006487 creator A5038512519 @default.
• W2116006487 creator A5050421438 @default.
• W2116006487 creator A5064486570 @default.
• W2116006487 creator A5065733629 @default.
• W2116006487 creator A5066244090 @default.
• W2116006487 creator A5086345118 @default.
• W2116006487 date "2008-02-27" @default.
• W2116006487 modified "2023-09-23" @default.
• W2116006487 title "Cysteinyl Leukotriene-1 Receptor Activation in a Human Bronchial Epithelial Cell Line Leads to Signal Transducer and Activator of Transcription 1-Mediated Eosinophil Adhesion" @default.
• W2116006487 cites W1584165754 @default.
• W2116006487 cites W1755902553 @default.
• W2116006487 cites W1922287625 @default.
• W2116006487 cites W1966791778 @default.
• W2116006487 cites W1969154550 @default.
• W2116006487 cites W1970696411 @default.
• W2116006487 cites W1973860290 @default.
• W2116006487 cites W1979407094 @default.
• W2116006487 cites W1983310583 @default.
• W2116006487 cites W1987485201 @default.
• W2116006487 cites W2003969944 @default.
• W2116006487 cites W2009640513 @default.
• W2116006487 cites W2028878799 @default.
• W2116006487 cites W2030865745 @default.
• W2116006487 cites W2045011622 @default.
• W2116006487 cites W2052355511 @default.
• W2116006487 cites W2059405490 @default.
• W2116006487 cites W2063748409 @default.
• W2116006487 cites W2068542139 @default.
• W2116006487 cites W2070665904 @default.
• W2116006487 cites W2072734944 @default.
• W2116006487 cites W2072963392 @default.
• W2116006487 cites W2080761559 @default.
• W2116006487 cites W2083162314 @default.
• W2116006487 cites W2083802827 @default.
• W2116006487 cites W2088483217 @default.
• W2116006487 cites W2109318901 @default.
• W2116006487 cites W2116594128 @default.
• W2116006487 cites W2117597586 @default.
• W2116006487 cites W2121022604 @default.
• W2116006487 cites W2126456110 @default.
• W2116006487 cites W2133162139 @default.
• W2116006487 cites W2137375900 @default.
• W2116006487 cites W2143209940 @default.
• W2116006487 cites W2143777769 @default.
• W2116006487 cites W2146938628 @default.
• W2116006487 cites W2152288642 @default.
• W2116006487 cites W2163744692 @default.
• W2116006487 cites W2173560213 @default.
• W2116006487 cites W2340562441 @default.
• W2116006487 doi "https://doi.org/10.1124/jpet.107.131649" @default.
• W2116006487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18305014" @default.
• W2116006487 hasPublicationYear "2008" @default.
• W2116006487 type Work @default.
• W2116006487 sameAs 2116006487 @default.
• W2116006487 citedByCount "30" @default.
• W2116006487 countsByYear W21160064872013 @default.
• W2116006487 countsByYear W21160064872015 @default.
• W2116006487 countsByYear W21160064872016 @default.
• W2116006487 countsByYear W21160064872018 @default.
• W2116006487 countsByYear W21160064872019 @default.
• W2116006487 countsByYear W21160064872020 @default.
• W2116006487 countsByYear W21160064872021 @default.
• W2116006487 crossrefType "journal-article" @default.
• W2116006487 hasAuthorship W2116006487A5002911229 @default.
• W2116006487 hasAuthorship W2116006487A5003759113 @default.
• W2116006487 hasAuthorship W2116006487A5025888123 @default.
• W2116006487 hasAuthorship W2116006487A5029667558 @default.
• W2116006487 hasAuthorship W2116006487A5038512519 @default.
• W2116006487 hasAuthorship W2116006487A5050421438 @default.
• W2116006487 hasAuthorship W2116006487A5064486570 @default.
• W2116006487 hasAuthorship W2116006487A5065733629 @default.
• W2116006487 hasAuthorship W2116006487A5066244090 @default.
• W2116006487 hasAuthorship W2116006487A5086345118 @default.
• W2116006487 hasConcept C153911025 @default.
• W2116006487 hasConcept C170493617 @default.
• W2116006487 hasConcept C171958077 @default.
• W2116006487 hasConcept C184235292 @default.
• W2116006487 hasConcept C185592680 @default.
• W2116006487 hasConcept C195794163 @default.
• W2116006487 hasConcept C203014093 @default.
• W2116006487 hasConcept C2776042228 @default.
• W2116006487 hasConcept C2777037409 @default.
• W2116006487 hasConcept C2777314051 @default.
• W2116006487 hasConcept C2778923194 @default.
• W2116006487 hasConcept C2781249067 @default.
• W2116006487 hasConcept C55493867 @default.
• W2116006487 hasConcept C57074206 @default.
• W2116006487 hasConcept C62478195 @default.
• W2116006487 hasConcept C86803240 @default.
• W2116006487 hasConcept C88045685 @default.
• W2116006487 hasConcept C95444343 @default.
• W2116006487 hasConceptScore W2116006487C153911025 @default.

• next