Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116019139> ?p ?o ?g. }
- W2116019139 endingPage "433.e10" @default.
- W2116019139 startingPage "433.e1" @default.
- W2116019139 abstract "To test the effects of adeno-associated virus encoding sFLT01 (AAV5.sFLT01) on the retinal lesions in Ccl2−/−/Cx3cr1−/− mice, a model for age-related macular degeneration (AMD), AAV5.sFLT01 was injected into the subretinal space of the right eyes and the left eyes served as controls. Histology found no retinal toxicity due to the treatment after 3 months. The treated eyes showed lesion arrest compared with lesion progression in the left eyes by fundus monitoring monthly and histological evaluation 3 months after treatment. Retinal ultrastructure showed fewer lipofuscin and better preserved photoreceptors after the treatment. A2E, a major component of lipofuscin, was lower in the treated eyes than in the control eyes. Molecular analysis showed that AAV5.sFLT01 lowered retinal extracellular signal-regulated kinase (ERK) phosphorylation and inducible nitric oxide synthetase expression, which suggested the involvement of reactive nitrogen species in the retinal lesions of Ccl2−/−/Cx3cr1−/−. We concluded that local delivery of AAV5.sFLT01 can stabilize retinal lesions in Ccl2−/−/Cx3cr1−/− mice. The findings provide further support for the potential beneficial effects of sFLT01 gene therapy for age-related macular degeneration." @default.
- W2116019139 created "2016-06-24" @default.
- W2116019139 creator A5001100231 @default.
- W2116019139 creator A5008889406 @default.
- W2116019139 creator A5035364814 @default.
- W2116019139 creator A5041399608 @default.
- W2116019139 creator A5055348574 @default.
- W2116019139 creator A5071672663 @default.
- W2116019139 creator A5072582941 @default.
- W2116019139 creator A5072687034 @default.
- W2116019139 creator A5073456146 @default.
- W2116019139 creator A5076578673 @default.
- W2116019139 creator A5078832914 @default.
- W2116019139 date "2012-02-01" @default.
- W2116019139 modified "2023-10-16" @default.
- W2116019139 title "AAV5-mediated sFLT01 gene therapy arrests retinal lesions in Ccl2−/−/Cx3cr1−/− mice" @default.
- W2116019139 cites W149497181 @default.
- W2116019139 cites W1562971597 @default.
- W2116019139 cites W1675915187 @default.
- W2116019139 cites W1968186746 @default.
- W2116019139 cites W1969157499 @default.
- W2116019139 cites W1977013517 @default.
- W2116019139 cites W1979056746 @default.
- W2116019139 cites W1989558725 @default.
- W2116019139 cites W1991157268 @default.
- W2116019139 cites W1995284319 @default.
- W2116019139 cites W1997480136 @default.
- W2116019139 cites W2015057944 @default.
- W2116019139 cites W2017391147 @default.
- W2116019139 cites W2023404740 @default.
- W2116019139 cites W2028358947 @default.
- W2116019139 cites W2032591467 @default.
- W2116019139 cites W2038140902 @default.
- W2116019139 cites W2043251036 @default.
- W2116019139 cites W2045050618 @default.
- W2116019139 cites W2049057765 @default.
- W2116019139 cites W2052836862 @default.
- W2116019139 cites W2057221200 @default.
- W2116019139 cites W2064790719 @default.
- W2116019139 cites W2070613014 @default.
- W2116019139 cites W2072484387 @default.
- W2116019139 cites W2073311838 @default.
- W2116019139 cites W2073714432 @default.
- W2116019139 cites W2078083828 @default.
- W2116019139 cites W2079984111 @default.
- W2116019139 cites W2081364421 @default.
- W2116019139 cites W2087711766 @default.
- W2116019139 cites W2093150080 @default.
- W2116019139 cites W2095577723 @default.
- W2116019139 cites W2106065339 @default.
- W2116019139 cites W2122311980 @default.
- W2116019139 cites W2127203245 @default.
- W2116019139 cites W2149419595 @default.
- W2116019139 cites W2160297253 @default.
- W2116019139 doi "https://doi.org/10.1016/j.neurobiolaging.2011.01.009" @default.
- W2116019139 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3136657" @default.
- W2116019139 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21397984" @default.
- W2116019139 hasPublicationYear "2012" @default.
- W2116019139 type Work @default.
- W2116019139 sameAs 2116019139 @default.
- W2116019139 citedByCount "22" @default.
- W2116019139 countsByYear W21160191392012 @default.
- W2116019139 countsByYear W21160191392013 @default.
- W2116019139 countsByYear W21160191392014 @default.
- W2116019139 countsByYear W21160191392015 @default.
- W2116019139 countsByYear W21160191392016 @default.
- W2116019139 countsByYear W21160191392017 @default.
- W2116019139 countsByYear W21160191392020 @default.
- W2116019139 countsByYear W21160191392022 @default.
- W2116019139 crossrefType "journal-article" @default.
- W2116019139 hasAuthorship W2116019139A5001100231 @default.
- W2116019139 hasAuthorship W2116019139A5008889406 @default.
- W2116019139 hasAuthorship W2116019139A5035364814 @default.
- W2116019139 hasAuthorship W2116019139A5041399608 @default.
- W2116019139 hasAuthorship W2116019139A5055348574 @default.
- W2116019139 hasAuthorship W2116019139A5071672663 @default.
- W2116019139 hasAuthorship W2116019139A5072582941 @default.
- W2116019139 hasAuthorship W2116019139A5072687034 @default.
- W2116019139 hasAuthorship W2116019139A5073456146 @default.
- W2116019139 hasAuthorship W2116019139A5076578673 @default.
- W2116019139 hasAuthorship W2116019139A5078832914 @default.
- W2116019139 hasBestOaLocation W21160191392 @default.
- W2116019139 hasConcept C118487528 @default.
- W2116019139 hasConcept C142724271 @default.
- W2116019139 hasConcept C169760540 @default.
- W2116019139 hasConcept C2776403814 @default.
- W2116019139 hasConcept C2777093970 @default.
- W2116019139 hasConcept C2780827179 @default.
- W2116019139 hasConcept C2781040256 @default.
- W2116019139 hasConcept C2781156865 @default.
- W2116019139 hasConcept C71924100 @default.
- W2116019139 hasConcept C86803240 @default.
- W2116019139 hasConceptScore W2116019139C118487528 @default.
- W2116019139 hasConceptScore W2116019139C142724271 @default.
- W2116019139 hasConceptScore W2116019139C169760540 @default.
- W2116019139 hasConceptScore W2116019139C2776403814 @default.
- W2116019139 hasConceptScore W2116019139C2777093970 @default.
- W2116019139 hasConceptScore W2116019139C2780827179 @default.