FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116035694> ?p ?o ?g. }

• W2116035694 endingPage "S715" @default.
• W2116035694 startingPage "S715" @default.
• W2116035694 abstract "Malignant pleural mesothelioma (MPM) is an aggressive tumor with disastrous prognosis. Many RT procedures, were evaluated to cover the large and irregular target and to limit the dose at the nearness risk structures. In this work the feasibility of volumetric modulated arcs therapy with RapidArc (RA) technique for adjuvant radiotherapy treatment of MPM was evaluated in comparison with fixed field IMRT. A retrospective analysis was performed on 6 patients affected by MPM and enrolled for adjuvant RT (3 left/right sides). The CTV was defined as the region of resection and other areas considered at high risk. The PTV was delineated by uniform margins of 5 mm around CTV. The plans were normalized at PTV mean dose, dose prescription was 54 Gy, with 2 Gy/fraction. For RapidArc two coplanar full arcs using 18 MV were used, whereas 9 fields with mix 6 and 18 MV energies were applied to IMRT plans. Planning objectives were: PTV: V95%>95%, controlateral lung: V5Gy<60%, V20Gy<10%, mean dose<9.5Gy, Liver: V30Gy<33%, mean dose<31Gy; Heart: V45Gy<30%, V50Gy<20%, DMax<60Gy; Spinal cord: V45Gy<1%, DMax<50Gy, Contralateral kidney: V15Gy<20%, Esophagus: V55Gy<30%, Spleen: V40Gy<50%. The plans were compared by analyzing target coverage, homogeneity and normal tissue sparing. Both IMRT and RA met the target objective on CTV (V95%=95.3±8.5 for IMRT and 98.7±1.4 for RA) and approached it on PTV (V95%=93.3±7.7 and 93.5±3.4). Target homogeneity resulted equivalent between RA (D5%-D95%=5.9±0.8) and IMRT (D5%-D95%=6.0±1.5). All the objectives for OARs were met for both techniques: contralateral mean lung doses were 5.8±0.8 and 5.6±0.7 Gy respectively for IMRT and RA, with V5Gy=45.0±12.6% and V20Gy=2.0±0.9% for IMRT, V5Gy =47.9±7.4% and V20Gy=0.4±0.4% for (RA). Heart resulted with IMRT V45Gy=15.6±4.0% and V50Gy=6.1±1.5%, while with RA V45Gy=19.2±11.5% and V50Gy=12.0±7.2%. Liver V30Gy was 15.1±12.8% and 12.8±14.0% with IMRT and RA, respectively. Spleen had V40Gy=39.4±6.3% with IMRT and 40.5±7.4% with RA. Esophagus V55Gy was 8.2±14.4% and 4.4±9.2% with IMRT and RA. V15Gy to contralateral kidney, as well as V45Gy to spine presented 0% volume for both techniques. For healthy tissue, integral dose resulted equivalent between the two techniques. Concerning delivery parameters, RapidArc resulted in reducing total monitor units 2195±317 for IMRT and 734±82 for RA. The dosimetric findings are significantly favorable for RapidArc and, from the clinical perspective, these data could increase the population candidate to RT of MPM after radical surgery. An upcoming Phase I trial on patients will start to evaluate the clinical outcomes with RapidArc." @default.
• W2116035694 created "2016-06-24" @default.
• W2116035694 creator A5014155191 @default.
• W2116035694 creator A5021349815 @default.
• W2116035694 creator A5023837255 @default.
• W2116035694 creator A5034426119 @default.
• W2116035694 creator A5048685622 @default.
• W2116035694 creator A5058093780 @default.
• W2116035694 creator A5071706202 @default.
• W2116035694 creator A5074179856 @default.
• W2116035694 creator A5087468389 @default.
• W2116035694 date "2009-11-01" @default.
• W2116035694 modified "2023-09-27" @default.
• W2116035694 title "Feasibility Study of Volumetric Modulated Arc Therapy for Malignant Pleural Mesothelioma Tumor" @default.
• W2116035694 doi "https://doi.org/10.1016/j.ijrobp.2009.07.1629" @default.
• W2116035694 hasPublicationYear "2009" @default.
• W2116035694 type Work @default.
• W2116035694 sameAs 2116035694 @default.
• W2116035694 citedByCount "0" @default.
• W2116035694 crossrefType "journal-article" @default.
• W2116035694 hasAuthorship W2116035694A5014155191 @default.
• W2116035694 hasAuthorship W2116035694A5021349815 @default.
• W2116035694 hasAuthorship W2116035694A5023837255 @default.
• W2116035694 hasAuthorship W2116035694A5034426119 @default.
• W2116035694 hasAuthorship W2116035694A5048685622 @default.
• W2116035694 hasAuthorship W2116035694A5058093780 @default.
• W2116035694 hasAuthorship W2116035694A5071706202 @default.
• W2116035694 hasAuthorship W2116035694A5074179856 @default.
• W2116035694 hasAuthorship W2116035694A5087468389 @default.
• W2116035694 hasBestOaLocation W21160356941 @default.
• W2116035694 hasConcept C126838900 @default.
• W2116035694 hasConcept C141071460 @default.
• W2116035694 hasConcept C142724271 @default.
• W2116035694 hasConcept C2777407522 @default.
• W2116035694 hasConcept C2777819096 @default.
• W2116035694 hasConcept C2989005 @default.
• W2116035694 hasConcept C509974204 @default.
• W2116035694 hasConcept C71924100 @default.
• W2116035694 hasConceptScore W2116035694C126838900 @default.
• W2116035694 hasConceptScore W2116035694C141071460 @default.
• W2116035694 hasConceptScore W2116035694C142724271 @default.
• W2116035694 hasConceptScore W2116035694C2777407522 @default.
• W2116035694 hasConceptScore W2116035694C2777819096 @default.
• W2116035694 hasConceptScore W2116035694C2989005 @default.
• W2116035694 hasConceptScore W2116035694C509974204 @default.
• W2116035694 hasConceptScore W2116035694C71924100 @default.
• W2116035694 hasIssue "3" @default.
• W2116035694 hasLocation W21160356941 @default.
• W2116035694 hasOpenAccess W2116035694 @default.
• W2116035694 hasPrimaryLocation W21160356941 @default.
• W2116035694 hasRelatedWork W2014435840 @default.
• W2116035694 hasRelatedWork W2022944059 @default.
• W2116035694 hasRelatedWork W2048191766 @default.
• W2116035694 hasRelatedWork W2070138482 @default.
• W2116035694 hasRelatedWork W2081773521 @default.
• W2116035694 hasRelatedWork W2155887765 @default.
• W2116035694 hasRelatedWork W2384708512 @default.
• W2116035694 hasRelatedWork W2415717579 @default.
• W2116035694 hasRelatedWork W2428341374 @default.
• W2116035694 hasRelatedWork W2473703456 @default.
• W2116035694 hasVolume "75" @default.
• W2116035694 isParatext "false" @default.
• W2116035694 isRetracted "false" @default.
• W2116035694 magId "2116035694" @default.
• W2116035694 workType "article" @default.