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- W2116041961 abstract "Abstract Three carbazole derivatives, O ‐methylmukonal (1), 3‐formyl‐2,7‐dimethoxycarbazole (2) and clauszoline J (3), and a pyranocoumarin, clausenidin (4), were isolated from the rhizomes and roots of Clausena excavata . Compound 1, isolated from this plant for the first time, has not been reported previously as having anti‐HIV‐1 activity. Compounds 1–4 displayed anti‐HIV‐1 activity in a syncytial assay with EC 50 values of 12, 29.1, 34.2 and 5.3 µ m , respectively, and thus exhibited potential therapeutic index (PTI) values of 56.7, 8.0, 1.6 and 7.0, respectively. All isolated compounds demonstrated a lack of cytotoxicity against the KB and BC‐1 cancer cell lines. Copyright © 2005 John Wiley & Sons, Ltd." @default.
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- W2116041961 date "2005-08-01" @default.
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- W2116041961 title "Anti-HIV-1 constituents fromClausena excavata: Part II. carbazoles and a pyranocoumarin" @default.
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- W2116041961 doi "https://doi.org/10.1002/ptr.1738" @default.
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