Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116053347> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2116053347 endingPage "60" @default.
- W2116053347 startingPage "55" @default.
- W2116053347 abstract "Objectives Polyglandular failure or autoimmunity (PGA) involves at least two endocrine diseases. Several genes may play a role in its etiology. This study analyzed 1) whether HLA-DRB1, HLA-DQB1, and MHC class I chain-related gene A (MICA) polymorphisms are associated in PGA and 2) whether PGA patients display stronger associations with these immune genes than patients with monoglandular autoimmunity (MGA). Design Association study. Methods HLA-DRB1, HLA-DQB1, and MICA alleles were analyzed in 73 patients with PGA, 283 with MGA, and 206 healthy controls. The HLA-DRB1 and HLA-DQB1 polymorphisms were determined with PCR-amplified DNA being hybridized with PCR-sequence-specific oligonucleotide probes. MICA microsatellites were typed by PCR amplification and fragment size analysis on a DNA sequencer. Results HLA-DRB1*03 was strongly increased in patients with PGA (50.7%) versus both controls (21.8%, P c <0.0001; RR=2.32, 95% CI=1.62–3.33) and MGA (11.4%, P c <0.0001). HLA-DRB1*03 was highly prevalent in PGA patients with early versus late disease onset ( P <0.05, logistic regression analysis). HLA-DRB1*04 allele carriers were more present in PGA versus controls (53.4% vs 22.4%, P c <0.0001, RR=2.38, 95% CI=1.68–3.38). Further, HLA-DQB1*02 was increased in PGA versus controls ( P c <0.01), whereas HLA-DQB1*06 was decreased ( P c <0.001). Patients with PGA showed more MIC A5.1 and less MIC A6 allele carriers than controls (NS). Presence of the MIC A5.1 allele was not associated with the HLA-DRB1*03 or HLA-DQB1 alleles. Conclusions HLA-DRB1*03 is a stronger genetic marker in PGA than in MGA, foremost in those with early disease onset." @default.
- W2116053347 created "2016-06-24" @default.
- W2116053347 creator A5002315623 @default.
- W2116053347 creator A5026278219 @default.
- W2116053347 creator A5050422212 @default.
- W2116053347 creator A5087797414 @default.
- W2116053347 date "2008-07-01" @default.
- W2116053347 modified "2023-10-01" @default.
- W2116053347 title "Early onset of polyglandular failure is associated with HLA-DRB1*03." @default.
- W2116053347 cites W1973964927 @default.
- W2116053347 cites W1974620306 @default.
- W2116053347 cites W2011407843 @default.
- W2116053347 cites W2024286178 @default.
- W2116053347 cites W2041086782 @default.
- W2116053347 cites W2048970828 @default.
- W2116053347 cites W2066800236 @default.
- W2116053347 cites W2090926976 @default.
- W2116053347 cites W2093069204 @default.
- W2116053347 cites W2093947788 @default.
- W2116053347 cites W2106507718 @default.
- W2116053347 cites W2123363789 @default.
- W2116053347 cites W2124725638 @default.
- W2116053347 cites W2138240417 @default.
- W2116053347 cites W2170069789 @default.
- W2116053347 cites W2170951158 @default.
- W2116053347 cites W4240916260 @default.
- W2116053347 cites W4243507883 @default.
- W2116053347 cites W4250468887 @default.
- W2116053347 cites W4251429771 @default.
- W2116053347 doi "https://doi.org/10.1530/eje-08-0082" @default.
- W2116053347 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18390988" @default.
- W2116053347 hasPublicationYear "2008" @default.
- W2116053347 type Work @default.
- W2116053347 sameAs 2116053347 @default.
- W2116053347 citedByCount "33" @default.
- W2116053347 countsByYear W21160533472012 @default.
- W2116053347 countsByYear W21160533472013 @default.
- W2116053347 countsByYear W21160533472014 @default.
- W2116053347 countsByYear W21160533472015 @default.
- W2116053347 countsByYear W21160533472016 @default.
- W2116053347 countsByYear W21160533472018 @default.
- W2116053347 countsByYear W21160533472019 @default.
- W2116053347 countsByYear W21160533472021 @default.
- W2116053347 countsByYear W21160533472022 @default.
- W2116053347 countsByYear W21160533472023 @default.
- W2116053347 crossrefType "journal-article" @default.
- W2116053347 hasAuthorship W2116053347A5002315623 @default.
- W2116053347 hasAuthorship W2116053347A5026278219 @default.
- W2116053347 hasAuthorship W2116053347A5050422212 @default.
- W2116053347 hasAuthorship W2116053347A5087797414 @default.
- W2116053347 hasBestOaLocation W21160533471 @default.
- W2116053347 hasConcept C104317684 @default.
- W2116053347 hasConcept C126322002 @default.
- W2116053347 hasConcept C134018914 @default.
- W2116053347 hasConcept C147483822 @default.
- W2116053347 hasConcept C180754005 @default.
- W2116053347 hasConcept C188280979 @default.
- W2116053347 hasConcept C203014093 @default.
- W2116053347 hasConcept C2779134260 @default.
- W2116053347 hasConcept C2780130043 @default.
- W2116053347 hasConcept C54355233 @default.
- W2116053347 hasConcept C71924100 @default.
- W2116053347 hasConcept C86803240 @default.
- W2116053347 hasConcept C90924648 @default.
- W2116053347 hasConceptScore W2116053347C104317684 @default.
- W2116053347 hasConceptScore W2116053347C126322002 @default.
- W2116053347 hasConceptScore W2116053347C134018914 @default.
- W2116053347 hasConceptScore W2116053347C147483822 @default.
- W2116053347 hasConceptScore W2116053347C180754005 @default.
- W2116053347 hasConceptScore W2116053347C188280979 @default.
- W2116053347 hasConceptScore W2116053347C203014093 @default.
- W2116053347 hasConceptScore W2116053347C2779134260 @default.
- W2116053347 hasConceptScore W2116053347C2780130043 @default.
- W2116053347 hasConceptScore W2116053347C54355233 @default.
- W2116053347 hasConceptScore W2116053347C71924100 @default.
- W2116053347 hasConceptScore W2116053347C86803240 @default.
- W2116053347 hasConceptScore W2116053347C90924648 @default.
- W2116053347 hasIssue "1" @default.
- W2116053347 hasLocation W21160533471 @default.
- W2116053347 hasLocation W21160533472 @default.
- W2116053347 hasOpenAccess W2116053347 @default.
- W2116053347 hasPrimaryLocation W21160533471 @default.
- W2116053347 hasRelatedWork W1966504330 @default.
- W2116053347 hasRelatedWork W1976029963 @default.
- W2116053347 hasRelatedWork W1979139803 @default.
- W2116053347 hasRelatedWork W2032620457 @default.
- W2116053347 hasRelatedWork W2037631372 @default.
- W2116053347 hasRelatedWork W2040058909 @default.
- W2116053347 hasRelatedWork W2132898409 @default.
- W2116053347 hasRelatedWork W2141923742 @default.
- W2116053347 hasRelatedWork W2748952813 @default.
- W2116053347 hasRelatedWork W3165665689 @default.
- W2116053347 hasVolume "159" @default.
- W2116053347 isParatext "false" @default.
- W2116053347 isRetracted "false" @default.
- W2116053347 magId "2116053347" @default.
- W2116053347 workType "article" @default.