Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116064782> ?p ?o ?g. }
- W2116064782 endingPage "1667" @default.
- W2116064782 startingPage "1657" @default.
- W2116064782 abstract "UNC-51 is a serine/threonine protein kinase conserved from yeast to humans. The yeast homolog Atg1 regulates autophagy (catabolic membrane trafficking) required for surviving starvation. In C. elegans, UNC-51 regulates the axon guidance of many neurons by a different mechanism than it and its homologs use for autophagy. UNC-51 regulates the subcellular localization (trafficking) of UNC-5, a receptor for the axon guidance molecule UNC-6/Netrin; however, the molecular details of the role for UNC-51 are largely unknown. Here, we report that UNC-51 physically interacts with LET-92, the catalytic subunit of serine/threonine protein phosphatase 2A (PP2A-C), which plays important roles in many cellular functions. A low allelic dose of LET-92 partially suppressed axon guidance defects of weak, but not severe, unc-51 mutants, and a low allelic dose of PP2A regulatory subunits A (PAA-1/PP2A-A) and B (SUR-6/PP2A-B) partially enhanced the weak unc-51 mutants. We also found that LET-92 can work cell-non-autonomously on axon guidance in neurons, and that LET-92 colocalized with UNC-51 in neurons. In addition, PP2A dephosphorylated phosphoproteins that had been phosphorylated by UNC-51. These results suggest that, by forming a complex, PP2A cooperates with UNC-51 to regulate axon guidance by regulating phosphorylation. This is the first report of a serine/threonine protein phosphatase functioning in axon guidance in vivo." @default.
- W2116064782 created "2016-06-24" @default.
- W2116064782 creator A5008630128 @default.
- W2116064782 creator A5016629898 @default.
- W2116064782 creator A5020422862 @default.
- W2116064782 creator A5032171375 @default.
- W2116064782 creator A5048426520 @default.
- W2116064782 creator A5072772526 @default.
- W2116064782 creator A5079049575 @default.
- W2116064782 date "2010-05-15" @default.
- W2116064782 modified "2023-10-04" @default.
- W2116064782 title "Protein phosphatase 2A cooperates with the autophagy-related kinase UNC-51 to regulate axon guidance in<i>Caenorhabditis elegans</i>" @default.
- W2116064782 cites W1505732106 @default.
- W2116064782 cites W1563901861 @default.
- W2116064782 cites W1750072934 @default.
- W2116064782 cites W1944127002 @default.
- W2116064782 cites W1966272997 @default.
- W2116064782 cites W1974923921 @default.
- W2116064782 cites W1976179891 @default.
- W2116064782 cites W1979576335 @default.
- W2116064782 cites W1981839201 @default.
- W2116064782 cites W1989952069 @default.
- W2116064782 cites W1990195067 @default.
- W2116064782 cites W1994222456 @default.
- W2116064782 cites W1994265088 @default.
- W2116064782 cites W1999793253 @default.
- W2116064782 cites W2000894674 @default.
- W2116064782 cites W2012109762 @default.
- W2116064782 cites W2024274815 @default.
- W2116064782 cites W2029458900 @default.
- W2116064782 cites W2033712349 @default.
- W2116064782 cites W2035455156 @default.
- W2116064782 cites W2036225486 @default.
- W2116064782 cites W2036473961 @default.
- W2116064782 cites W2036901614 @default.
- W2116064782 cites W2037828336 @default.
- W2116064782 cites W2038638713 @default.
- W2116064782 cites W2039210066 @default.
- W2116064782 cites W2042200157 @default.
- W2116064782 cites W2042629507 @default.
- W2116064782 cites W2043260620 @default.
- W2116064782 cites W2044481116 @default.
- W2116064782 cites W2046064274 @default.
- W2116064782 cites W2046347212 @default.
- W2116064782 cites W2046407078 @default.
- W2116064782 cites W2047293798 @default.
- W2116064782 cites W2051821597 @default.
- W2116064782 cites W2052711805 @default.
- W2116064782 cites W2053384096 @default.
- W2116064782 cites W2055770612 @default.
- W2116064782 cites W2055793572 @default.
- W2116064782 cites W2059520792 @default.
- W2116064782 cites W2061561213 @default.
- W2116064782 cites W2062708599 @default.
- W2116064782 cites W2062712010 @default.
- W2116064782 cites W2066727453 @default.
- W2116064782 cites W2067518266 @default.
- W2116064782 cites W2068209211 @default.
- W2116064782 cites W2068383029 @default.
- W2116064782 cites W2070516049 @default.
- W2116064782 cites W2076570319 @default.
- W2116064782 cites W2079220144 @default.
- W2116064782 cites W2083669494 @default.
- W2116064782 cites W2086440896 @default.
- W2116064782 cites W2089030810 @default.
- W2116064782 cites W2090443124 @default.
- W2116064782 cites W2090865074 @default.
- W2116064782 cites W2094900302 @default.
- W2116064782 cites W2098743384 @default.
- W2116064782 cites W2104968565 @default.
- W2116064782 cites W2107913200 @default.
- W2116064782 cites W2113185199 @default.
- W2116064782 cites W2115160770 @default.
- W2116064782 cites W2115734610 @default.
- W2116064782 cites W2117345715 @default.
- W2116064782 cites W2118731910 @default.
- W2116064782 cites W2122103373 @default.
- W2116064782 cites W2122163057 @default.
- W2116064782 cites W2124248841 @default.
- W2116064782 cites W2124440591 @default.
- W2116064782 cites W2128321615 @default.
- W2116064782 cites W2129047394 @default.
- W2116064782 cites W2130292044 @default.
- W2116064782 cites W2132818618 @default.
- W2116064782 cites W2136584599 @default.
- W2116064782 cites W2149813111 @default.
- W2116064782 cites W2157183880 @default.
- W2116064782 cites W2160938187 @default.
- W2116064782 cites W2164494941 @default.
- W2116064782 cites W2164591040 @default.
- W2116064782 cites W2165421630 @default.
- W2116064782 cites W2168389877 @default.
- W2116064782 cites W2171247261 @default.
- W2116064782 cites W2171288353 @default.
- W2116064782 cites W2171845995 @default.
- W2116064782 cites W2314933212 @default.
- W2116064782 doi "https://doi.org/10.1242/dev.050708" @default.
- W2116064782 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3188576" @default.