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- W2116066344 abstract "Many spices, including plants of the ginger family, possess anticarcinogenic activity. However, the molecular mechanisms by which they exert their antitumorigenic effects are unknown. Activator protein 1 (AP-1) has a critical role in tumor promotion, and blocking of tumor promoter-induced activation of AP-1 inhibits neoplastic transformation. Epidermal growth factor induces cell transformation and AP-1 activity. The purpose of this study was to investigate the effect of two structurally related compounds of the ginger family, [6]-gingerol and [6]-paradol, on EGF-induced cell transformation and AP-1 activation. Our results provide the first evidence that both block EGF-induced cell transformation but act by different mechanisms." @default.
- W2116066344 created "2016-06-24" @default.
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- W2116066344 date "2001-02-01" @default.
- W2116066344 modified "2023-10-12" @default.
- W2116066344 title "Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol." @default.
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