FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116069083> ?p ?o ?g. }

• W2116069083 endingPage "1007" @default.
• W2116069083 startingPage "1000" @default.
• W2116069083 abstract "Fetal drug exposure is determined by the type and concentration of placental transporters, and their regulation is central to the development of new treatments and delivery strategies for pregnant women and their fetuses. We tested the expression of several clinically important transporters in the human placenta associated with various pregnancy conditions (i.e., labor, preeclampsia, and preterm labor-inflammation). Placentas were obtained from five groups of women at the time of primary cesarean section: 1) term no labor; 2) term labor; 3) preterm no labor (delivered for severe preeclampsia); 4) preterm labor without inflammation (PTLNI); and 5) preterm labor with inflammation (PTLI). Samples were analyzed by Western blot and immunohistochemistry to identify changes in protein expression. Relative mRNA expression was determined by quantitative real-time polymerase chain reaction. A functional genomic approach was used to identify placental gene expression and elucidate molecular events that underlie the given condition. Placental expression of ATP-binding cassette transporters from women in labor and women with preeclampsia was unaltered. Multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP) and mRNA expression increased in placentas of women with preterm labor with inflammation. Molecular pathways of genes up-regulated in PTLI samples included cytokine-cytokine receptor interactions and inflammatory response compared with those in the PTLNI group. The mRNA expression of MDR1 and BCRP was correlated with that of interleukin-8, which also increased significantly in PTLI samples. These data suggest that the transfer of drugs across the placenta may be altered in preterm pregnancy conditions associated with inflammation through changes in MDR1 and BCRP." @default.
• W2116069083 created "2016-06-24" @default.
• W2116069083 creator A5022706310 @default.
• W2116069083 creator A5042743314 @default.
• W2116069083 creator A5066655749 @default.
• W2116069083 creator A5068713054 @default.
• W2116069083 creator A5074359125 @default.
• W2116069083 creator A5075933144 @default.
• W2116069083 date "2011-03-23" @default.
• W2116069083 modified "2023-10-09" @default.
• W2116069083 title "ATP-Binding Cassette Transporter Expression in Human Placenta as a Function of Pregnancy Condition" @default.
• W2116069083 cites W1743411717 @default.
• W2116069083 cites W1866641948 @default.
• W2116069083 cites W1965127293 @default.
• W2116069083 cites W1965959614 @default.
• W2116069083 cites W1970172365 @default.
• W2116069083 cites W1976583362 @default.
• W2116069083 cites W1978953108 @default.
• W2116069083 cites W1989666280 @default.
• W2116069083 cites W2004009238 @default.
• W2116069083 cites W2014795702 @default.
• W2116069083 cites W2014922269 @default.
• W2116069083 cites W2021031411 @default.
• W2116069083 cites W2032066050 @default.
• W2116069083 cites W2038167014 @default.
• W2116069083 cites W2044122327 @default.
• W2116069083 cites W2044429819 @default.
• W2116069083 cites W2044935825 @default.
• W2116069083 cites W2049633149 @default.
• W2116069083 cites W2061910554 @default.
• W2116069083 cites W2064188091 @default.
• W2116069083 cites W2068605087 @default.
• W2116069083 cites W2072954867 @default.
• W2116069083 cites W2079785947 @default.
• W2116069083 cites W2081098333 @default.
• W2116069083 cites W2090083061 @default.
• W2116069083 cites W2090369207 @default.
• W2116069083 cites W2092099719 @default.
• W2116069083 cites W2093297333 @default.
• W2116069083 cites W2101659891 @default.
• W2116069083 cites W2107277218 @default.
• W2116069083 cites W2110060881 @default.
• W2116069083 cites W2111020493 @default.
• W2116069083 cites W2113283528 @default.
• W2116069083 cites W2118207487 @default.
• W2116069083 cites W2148042336 @default.
• W2116069083 cites W2157466320 @default.
• W2116069083 cites W2158217645 @default.
• W2116069083 cites W2158850345 @default.
• W2116069083 cites W2162802890 @default.
• W2116069083 cites W2164258524 @default.
• W2116069083 cites W2171224841 @default.
• W2116069083 doi "https://doi.org/10.1124/dmd.111.038166" @default.
• W2116069083 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3100901" @default.
• W2116069083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21430233" @default.
• W2116069083 hasPublicationYear "2011" @default.
• W2116069083 type Work @default.
• W2116069083 sameAs 2116069083 @default.
• W2116069083 citedByCount "52" @default.
• W2116069083 countsByYear W21160690832012 @default.
• W2116069083 countsByYear W21160690832013 @default.
• W2116069083 countsByYear W21160690832014 @default.
• W2116069083 countsByYear W21160690832015 @default.
• W2116069083 countsByYear W21160690832016 @default.
• W2116069083 countsByYear W21160690832017 @default.
• W2116069083 countsByYear W21160690832018 @default.
• W2116069083 countsByYear W21160690832019 @default.
• W2116069083 countsByYear W21160690832020 @default.
• W2116069083 countsByYear W21160690832021 @default.
• W2116069083 countsByYear W21160690832022 @default.
• W2116069083 countsByYear W21160690832023 @default.
• W2116069083 crossrefType "journal-article" @default.
• W2116069083 hasAuthorship W2116069083A5022706310 @default.
• W2116069083 hasAuthorship W2116069083A5042743314 @default.
• W2116069083 hasAuthorship W2116069083A5066655749 @default.
• W2116069083 hasAuthorship W2116069083A5068713054 @default.
• W2116069083 hasAuthorship W2116069083A5074359125 @default.
• W2116069083 hasAuthorship W2116069083A5075933144 @default.
• W2116069083 hasBestOaLocation W21160690832 @default.
• W2116069083 hasConcept C104317684 @default.
• W2116069083 hasConcept C126322002 @default.
• W2116069083 hasConcept C134018914 @default.
• W2116069083 hasConcept C149011108 @default.
• W2116069083 hasConcept C150194340 @default.
• W2116069083 hasConcept C16685009 @default.
• W2116069083 hasConcept C168785527 @default.
• W2116069083 hasConcept C172680121 @default.
• W2116069083 hasConcept C203014093 @default.
• W2116069083 hasConcept C2776415932 @default.
• W2116069083 hasConcept C2776914184 @default.
• W2116069083 hasConcept C2776953305 @default.
• W2116069083 hasConcept C2777218350 @default.
• W2116069083 hasConcept C2778690821 @default.
• W2116069083 hasConcept C2779234561 @default.
• W2116069083 hasConcept C44312359 @default.
• W2116069083 hasConcept C48023723 @default.
• W2116069083 hasConcept C512196 @default.
• W2116069083 hasConcept C54355233 @default.

• next