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- W2116073148 abstract "Guinea-pigs immunized with alum-precipitated diphtheria toxoid (APT) become hypersensitive to diphtheria toxin and toxid. This hypersensitivity is probably due to a mixture of immediate (Arthus-type) reactions and delayed (tuberculin-type) reactions, the former increasing as the level of circulating precipitating antitoxin rose and tending to mask the latter. In a hyperimmune guinea-pig the residual damage following the intradermal injection of toxin is due, at least in part, to hypersensitivity to toxin; toxicity probably contributes relatively little to the extent of the lesion in animals with a high titre of antitoxin. The technical difficulties of proving the presence of a delayed allergic reaction in animals with an early allergic reaction are discussed. I am grateful to Dr C. G. Pope, who has been closely associated with this work, not only for providing highly purified materials, but also for his advice." @default.
- W2116073148 created "2016-06-24" @default.
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- W2116073148 date "1959-06-01" @default.
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- W2116073148 title "Immune and allergic reactions to diphtheria toxin and toxoid in guinea-pigs" @default.
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- W2116073148 doi "https://doi.org/10.1017/s0022172400020064" @default.
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