Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116095291> ?p ?o ?g. }
- W2116095291 endingPage "883" @default.
- W2116095291 startingPage "875" @default.
- W2116095291 abstract "The development of effector and memory CD4 cell populations depends upon both T cell receptor (TCR) engagement of peptide/major histocompatibility complex (MHC) class II complexes and ligation of costimulatory molecules with counter receptors on antigen-presenting cells (APCs). We showed previously that sustained interactions with APCs could be crucial for optimal expansion of CD4 cells and for development of effectors that secrete cytokines associated with Th2 cells. Using an adoptive transfer model with TCR transgenic CD4 cells, we now show that responses of CD4 cells primed in B cell-deficient mice become aborted, but are fully restored upon the transfer of activated B cells. Although B cells have the capacity to secrete multiple cytokines that could affect CD4 priming, including IL-4, we were unable to distinguish a role for cytokines that are secreted by B cells. However, B cell costimulation via the OX40L/OX40 pathway that has been implicated in CD4 cell expansion, survival, and Th2 development was required. Th2 but not Th1 responses were impaired in OX40L-deficient recipients and normal responses were restored with OX40L sufficient B cells. The results suggest that without engagement of OX40L on B cells, CD4 cell responses to many protein Ag would be dominated by Th1 cytokines. These data have important implications for strategies to achieve optimal priming of CD4 subsets." @default.
- W2116095291 created "2016-06-24" @default.
- W2116095291 creator A5006583994 @default.
- W2116095291 creator A5015191354 @default.
- W2116095291 creator A5020853472 @default.
- W2116095291 creator A5029595645 @default.
- W2116095291 creator A5038780661 @default.
- W2116095291 creator A5059646587 @default.
- W2116095291 creator A5067171210 @default.
- W2116095291 creator A5083714414 @default.
- W2116095291 date "2003-03-31" @default.
- W2116095291 modified "2023-10-12" @default.
- W2116095291 title "Costimulation via OX40L Expressed by B Cells Is Sufficient to Determine the Extent of Primary CD4 Cell Expansion and Th2 Cytokine Secretion In Vivo" @default.
- W2116095291 cites W1483505300 @default.
- W2116095291 cites W1489480103 @default.
- W2116095291 cites W1547450219 @default.
- W2116095291 cites W1549435714 @default.
- W2116095291 cites W1552852054 @default.
- W2116095291 cites W1558372199 @default.
- W2116095291 cites W1602037964 @default.
- W2116095291 cites W1626388077 @default.
- W2116095291 cites W1642812308 @default.
- W2116095291 cites W1946226823 @default.
- W2116095291 cites W1968054754 @default.
- W2116095291 cites W1977523123 @default.
- W2116095291 cites W1992949591 @default.
- W2116095291 cites W2005396825 @default.
- W2116095291 cites W2017624184 @default.
- W2116095291 cites W2028809209 @default.
- W2116095291 cites W2040066315 @default.
- W2116095291 cites W2045720698 @default.
- W2116095291 cites W2057146995 @default.
- W2116095291 cites W2065655094 @default.
- W2116095291 cites W2071969437 @default.
- W2116095291 cites W2073391461 @default.
- W2116095291 cites W2077565043 @default.
- W2116095291 cites W2087843772 @default.
- W2116095291 cites W2091301099 @default.
- W2116095291 cites W2107653794 @default.
- W2116095291 cites W2116562412 @default.
- W2116095291 cites W2117623357 @default.
- W2116095291 cites W2121841446 @default.
- W2116095291 cites W2126217474 @default.
- W2116095291 cites W2132830324 @default.
- W2116095291 cites W2133654601 @default.
- W2116095291 cites W2137639957 @default.
- W2116095291 cites W2142209244 @default.
- W2116095291 cites W2142721568 @default.
- W2116095291 cites W2143488332 @default.
- W2116095291 cites W2153268818 @default.
- W2116095291 cites W2154241904 @default.
- W2116095291 cites W2162472045 @default.
- W2116095291 cites W2163351493 @default.
- W2116095291 cites W2164832071 @default.
- W2116095291 doi "https://doi.org/10.1084/jem.20021290" @default.
- W2116095291 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2193894" @default.
- W2116095291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12668647" @default.
- W2116095291 hasPublicationYear "2003" @default.
- W2116095291 type Work @default.
- W2116095291 sameAs 2116095291 @default.
- W2116095291 citedByCount "223" @default.
- W2116095291 countsByYear W21160952912012 @default.
- W2116095291 countsByYear W21160952912013 @default.
- W2116095291 countsByYear W21160952912014 @default.
- W2116095291 countsByYear W21160952912015 @default.
- W2116095291 countsByYear W21160952912016 @default.
- W2116095291 countsByYear W21160952912017 @default.
- W2116095291 countsByYear W21160952912018 @default.
- W2116095291 countsByYear W21160952912019 @default.
- W2116095291 countsByYear W21160952912020 @default.
- W2116095291 countsByYear W21160952912021 @default.
- W2116095291 countsByYear W21160952912022 @default.
- W2116095291 countsByYear W21160952912023 @default.
- W2116095291 crossrefType "journal-article" @default.
- W2116095291 hasAuthorship W2116095291A5006583994 @default.
- W2116095291 hasAuthorship W2116095291A5015191354 @default.
- W2116095291 hasAuthorship W2116095291A5020853472 @default.
- W2116095291 hasAuthorship W2116095291A5029595645 @default.
- W2116095291 hasAuthorship W2116095291A5038780661 @default.
- W2116095291 hasAuthorship W2116095291A5059646587 @default.
- W2116095291 hasAuthorship W2116095291A5067171210 @default.
- W2116095291 hasAuthorship W2116095291A5083714414 @default.
- W2116095291 hasBestOaLocation W21160952911 @default.
- W2116095291 hasConcept C100701293 @default.
- W2116095291 hasConcept C134018914 @default.
- W2116095291 hasConcept C147483822 @default.
- W2116095291 hasConcept C154317977 @default.
- W2116095291 hasConcept C19317047 @default.
- W2116095291 hasConcept C202751555 @default.
- W2116095291 hasConcept C203014093 @default.
- W2116095291 hasConcept C207936829 @default.
- W2116095291 hasConcept C2776090121 @default.
- W2116095291 hasConcept C2778690821 @default.
- W2116095291 hasConcept C39347974 @default.
- W2116095291 hasConcept C49039625 @default.
- W2116095291 hasConcept C55493867 @default.
- W2116095291 hasConcept C59822182 @default.
- W2116095291 hasConcept C67662055 @default.