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• W2116099413 abstract "Abstract The diagnosis of neurological disease (ND) traditionally involves the association of specific symptoms in a patient with a clinical examination, consideration of the patient's prior medical history, and clinical laboratory testing (e.g., electroencephalography, electromyography). The decoding of the human genome has made possible the identification of proteomic and genomic biomarkers associated with specific neurological disorders. The identification of multiple biomarkers, including determination of chemical nature and concentration, provides a disease “signature” that is not achievable through testing for any single marker alone. Biomarker signatures can augment conventional clinical evaluation and testing by improving diagnosis, prognosis, monitoring progression, and management of ND. Biomarker signature profiling for a patient can allow for personalized medicine catered to individual need. The need for biosensors in the detection of ND is illustrated by recent events. Two cases of bovine spongiform encephalopathy (BSE) in Canada have cost their beef industry millions of dollars and resulted in precluding shipment of cattle from Canada to the United States. The ability to determine absence of prion disease in live cattle could greatly increase confidence in cattle imports. In a separate example, Tysabri, an immunosuppressant drug effective in lengthening periods of remission in patients with multiple sclerosis (MS), was withdrawn from the market because of occurrence of progressive multifocal leukoencephalopathy (PML) in treated individuals. PML in the treated MS individuals was caused by proliferation of JC virus. The ability to detect JC virus production during treatment with Tysabri could remedy this problem. Biosensors designed to detect analytes indicative of disease are currently available. Ranging from single target detection to more complex multitarget signature profiling, these biosensors are offered for a wide range of disorders. Many focus on the detection of cancer and ND. The platforms used for cancer detection are directly applicable to ND determination because the sensors detect analytes or genetic mutations present in both disease types. Specific products and technologies that are already being used for or can be readily adapted to ND diagnosis, prognosis, and treatment are discussed. A select list of ND‐related biomarkers for current and future study is presented." @default.
• W2116099413 created "2016-06-24" @default.
• W2116099413 creator A5046542837 @default.
• W2116099413 creator A5059594631 @default.
• W2116099413 date "2007-07-27" @default.
• W2116099413 modified "2023-09-23" @default.
• W2116099413 title "Biosensors for Neurological Disease" @default.
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• W2116099413 doi "https://doi.org/10.1002/9780470061565.hbb139" @default.
• W2116099413 hasPublicationYear "2007" @default.
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