FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116113310> ?p ?o ?g. }

• W2116113310 endingPage "3149" @default.
• W2116113310 startingPage "3138" @default.
• W2116113310 abstract "ABSTRACT Defining the antiviral efficacy of CD8 T cells is important for immunogen design, and yet most current assays do not measure the ability of responses to neutralize infectious virus. Here we show that human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte (CTL) clones and cell lines derived from infected persons and targeting diverse epitopes differ by over 1,000-fold in their ability to retard infectious virus replication in autologous CD4 T cells during a 7-day period in vitro, despite comparable activity as assessed by gamma interferon (IFN-γ) enzyme-linked immunospot (ELISPOT) assay. Cell lines derived from peripheral blood mononuclear cells stimulated in vitro with peptides representing targeted Gag epitopes consistently neutralized HIV better than Env-specific lines from the same person, although ineffective inhibition of virus replication is not a universal characteristic of Env-specific responses at the clonal level. Gag-specific cell lines were of higher avidity than Env-specific lines, although avidity did not correlate with the ability of Gag- or Env-specific lines to contain HIV replication. The greatest inhibition was observed with cell lines restricted by the protective HLA alleles B*27 and B*57, but stimulation with targeted Gag epitopes resulted in greater inhibition than did stimulation with targeted Env epitopes even in non-B*27/B*57 subjects. These results assessing functional virus neutralization by HIV-specific CD8 T cells indicate that there are marked epitope- and allele-specific differences in virus neutralization by in vitro-expanded CD8 T cells, a finding not revealed by standard IFN-γ ELISPOT assay currently in use in vaccine trials, which may be of critical importance in immunogen design and testing of candidate AIDS vaccines." @default.
• W2116113310 created "2016-06-24" @default.
• W2116113310 creator A5010079560 @default.
• W2116113310 creator A5016518899 @default.
• W2116113310 creator A5018486460 @default.
• W2116113310 creator A5021397351 @default.
• W2116113310 creator A5034313733 @default.
• W2116113310 creator A5045215070 @default.
• W2116113310 creator A5057265252 @default.
• W2116113310 creator A5059320234 @default.
• W2116113310 creator A5068585882 @default.
• W2116113310 creator A5076217842 @default.
• W2116113310 creator A5086950889 @default.
• W2116113310 creator A5088814115 @default.
• W2116113310 creator A5089480186 @default.
• W2116113310 date "2009-04-01" @default.
• W2116113310 modified "2023-09-27" @default.
• W2116113310 title "Differential Neutralization of Human Immunodeficiency Virus (HIV) Replication in Autologous CD4 T Cells by HIV-Specific Cytotoxic T Lymphocytes" @default.
• W2116113310 cites W1565230971 @default.
• W2116113310 cites W1890058237 @default.
• W2116113310 cites W1965681845 @default.
• W2116113310 cites W1978436252 @default.
• W2116113310 cites W1986152436 @default.
• W2116113310 cites W1994800735 @default.
• W2116113310 cites W2001815433 @default.
• W2116113310 cites W2019185875 @default.
• W2116113310 cites W2023890537 @default.
• W2116113310 cites W2039456204 @default.
• W2116113310 cites W2039473791 @default.
• W2116113310 cites W2039751597 @default.
• W2116113310 cites W2045551237 @default.
• W2116113310 cites W2046775408 @default.
• W2116113310 cites W2049932413 @default.
• W2116113310 cites W2068906161 @default.
• W2116113310 cites W2079280846 @default.
• W2116113310 cites W2085919513 @default.
• W2116113310 cites W2090646713 @default.
• W2116113310 cites W2098822919 @default.
• W2116113310 cites W2106628454 @default.
• W2116113310 cites W2118115182 @default.
• W2116113310 cites W2118619556 @default.
• W2116113310 cites W2120310223 @default.
• W2116113310 cites W2123286726 @default.
• W2116113310 cites W2127421167 @default.
• W2116113310 cites W2128843868 @default.
• W2116113310 cites W2134916334 @default.
• W2116113310 cites W2138575726 @default.
• W2116113310 cites W2142405752 @default.
• W2116113310 cites W2144956326 @default.
• W2116113310 cites W2146291971 @default.
• W2116113310 cites W2147134928 @default.
• W2116113310 cites W2151651155 @default.
• W2116113310 cites W2158240501 @default.
• W2116113310 cites W2160925670 @default.
• W2116113310 cites W2162170852 @default.
• W2116113310 doi "https://doi.org/10.1128/jvi.02073-08" @default.
• W2116113310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2655558" @default.
• W2116113310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19158248" @default.
• W2116113310 hasPublicationYear "2009" @default.
• W2116113310 type Work @default.
• W2116113310 sameAs 2116113310 @default.
• W2116113310 citedByCount "84" @default.
• W2116113310 countsByYear W21161133102012 @default.
• W2116113310 countsByYear W21161133102013 @default.
• W2116113310 countsByYear W21161133102014 @default.
• W2116113310 countsByYear W21161133102015 @default.
• W2116113310 countsByYear W21161133102016 @default.
• W2116113310 countsByYear W21161133102017 @default.
• W2116113310 countsByYear W21161133102018 @default.
• W2116113310 countsByYear W21161133102019 @default.
• W2116113310 countsByYear W21161133102020 @default.
• W2116113310 countsByYear W21161133102021 @default.
• W2116113310 countsByYear W21161133102022 @default.
• W2116113310 crossrefType "journal-article" @default.
• W2116113310 hasAuthorship W2116113310A5010079560 @default.
• W2116113310 hasAuthorship W2116113310A5016518899 @default.
• W2116113310 hasAuthorship W2116113310A5018486460 @default.
• W2116113310 hasAuthorship W2116113310A5021397351 @default.
• W2116113310 hasAuthorship W2116113310A5034313733 @default.
• W2116113310 hasAuthorship W2116113310A5045215070 @default.
• W2116113310 hasAuthorship W2116113310A5057265252 @default.
• W2116113310 hasAuthorship W2116113310A5059320234 @default.
• W2116113310 hasAuthorship W2116113310A5068585882 @default.
• W2116113310 hasAuthorship W2116113310A5076217842 @default.
• W2116113310 hasAuthorship W2116113310A5086950889 @default.
• W2116113310 hasAuthorship W2116113310A5088814115 @default.
• W2116113310 hasAuthorship W2116113310A5089480186 @default.
• W2116113310 hasBestOaLocation W21161133102 @default.
• W2116113310 hasConcept C140704245 @default.
• W2116113310 hasConcept C147483822 @default.
• W2116113310 hasConcept C154317977 @default.
• W2116113310 hasConcept C159047783 @default.
• W2116113310 hasConcept C159654299 @default.
• W2116113310 hasConcept C167672396 @default.
• W2116113310 hasConcept C179223381 @default.
• W2116113310 hasConcept C195616568 @default.
• W2116113310 hasConcept C202751555 @default.
• W2116113310 hasConcept C203014093 @default.

• next