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- W2116116840 abstract "Two new pentacyclic indole alkaloids, lirofolines A and B, possessing a novel rearranged ibogan ring system, are obtained from two Malayan Tabernaemontana species (Tabernaemontana corymbosa and Tabernaemontana divaricata) and the structures are established by analysis of the spectroscopic data. A biomimetic partial synthesis of lirofoline A from ibogaine via the Polonovski reaction is carried out. Lirofolines A and B showed significant activity in reversing multidrug resistance in vincristine-resistant KB cells (IC50 3.4 and 7.5 μg/ml, respectively)." @default.
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- W2116116840 date "2010-01-01" @default.
- W2116116840 modified "2023-09-30" @default.
- W2116116840 title "Structure, biological activity, and a biomimetic partial synthesis of the lirofolines, novel pentacylic indole alkaloids from Tabernaemontana" @default.
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- W2116116840 doi "https://doi.org/10.1016/j.tetlet.2009.10.122" @default.
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