Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116144264> ?p ?o ?g. }
- W2116144264 endingPage "35" @default.
- W2116144264 startingPage "16" @default.
- W2116144264 abstract "Background Trigeminal neuralgia is a disorder of paroxysmal and severely disabling facial pain and continues to be a real therapeutic challenge. At present there are few effective drugs. Here the aim of this study was to investigate the role of BK Ca channels in trigeminal neuropathic pain. Methods Rats were divided into two groups: a sham and a chronic constriction injury of infraorbital branch of trigeminal nerve (ION-CCI) group. Nociceptive behavior testing, immunohistochemistry, RT-PCR, Western blotting and whole-cell patch clamp recording were used. Results Relative to the sham group, rats with ION-CCI consistently displayed lower mechanical pain thresholds in the vibrissal pad region from day 6 to 42 after ION-CCI operation. ION-CCI induced a significant down-regulation of BK Ca channels both in mRNA and protein levels in the ipsilateral trigeminal ganglion (TG), a lower threshold intensity of action potential, and decreased total BK Ca currents in cultured TG neurons. TG target injection of NS1619 (20–100 µg), an opener of BK Ca channels, dose-dependently increased the mechanical pain threshold, which was blocked by the BK Ca channel inhibitor iberiotoxin (IbTX, 20 µg). NS1619 (10 µM) significantly increased the mean threshold intensities of action potentials in ION-CCI rats, while failing to affect those in the sham rats. The levels of phosphorylated extracellular signal-regulated kinase (ERK), p38 and c-Jun N-terminal kinases (JNK) in TG were significantly increased after ION-CCI operation. The ERK1/2 antagonist U0126, p38 antagonist SB203580 and JNK antagonist SP600125 significantly reversed the facial mechanical allodynia in ION-CCI rats. However, the ERK1/2 antagonist U0126, p38 antagonist SB203580 but not JNK antagonist SP600125 significantly increased BK Ca currents in ION-CCI TG neurons. Conclusions Our results indicate the important involvement of mainly ERK and p38 MAPK pathways in modulating BK Ca channels in ION-CCI TG neurons. BK Ca channels represent a new therapeutic target for the clinical treatment of trigeminal neuropathic pain." @default.
- W2116144264 created "2016-06-24" @default.
- W2116144264 creator A5024712968 @default.
- W2116144264 creator A5031315906 @default.
- W2116144264 creator A5031930208 @default.
- W2116144264 creator A5041565688 @default.
- W2116144264 creator A5041826783 @default.
- W2116144264 creator A5086768758 @default.
- W2116144264 date "2014-05-12" @default.
- W2116144264 modified "2023-10-16" @default.
- W2116144264 title "The role of large-conductance, calcium-activated potassium channels in a rat model of trigeminal neuropathic pain" @default.
- W2116144264 cites W1604744466 @default.
- W2116144264 cites W1626920804 @default.
- W2116144264 cites W1919059205 @default.
- W2116144264 cites W1959229569 @default.
- W2116144264 cites W1963857381 @default.
- W2116144264 cites W1967081222 @default.
- W2116144264 cites W1971038847 @default.
- W2116144264 cites W1974055192 @default.
- W2116144264 cites W1984861197 @default.
- W2116144264 cites W1985163057 @default.
- W2116144264 cites W1987118766 @default.
- W2116144264 cites W1989245704 @default.
- W2116144264 cites W1991092840 @default.
- W2116144264 cites W1991882776 @default.
- W2116144264 cites W1993807664 @default.
- W2116144264 cites W1999040914 @default.
- W2116144264 cites W2000696560 @default.
- W2116144264 cites W2002811636 @default.
- W2116144264 cites W2003542915 @default.
- W2116144264 cites W2008261130 @default.
- W2116144264 cites W2008388511 @default.
- W2116144264 cites W2017515163 @default.
- W2116144264 cites W2023771303 @default.
- W2116144264 cites W2024794798 @default.
- W2116144264 cites W2027916575 @default.
- W2116144264 cites W2035559994 @default.
- W2116144264 cites W2039553650 @default.
- W2116144264 cites W2041815912 @default.
- W2116144264 cites W2045375281 @default.
- W2116144264 cites W2046806142 @default.
- W2116144264 cites W2048223574 @default.
- W2116144264 cites W2048374630 @default.
- W2116144264 cites W2048385760 @default.
- W2116144264 cites W2049381901 @default.
- W2116144264 cites W2051844633 @default.
- W2116144264 cites W2053259499 @default.
- W2116144264 cites W2054361538 @default.
- W2116144264 cites W2056455715 @default.
- W2116144264 cites W2056552455 @default.
- W2116144264 cites W2058020736 @default.
- W2116144264 cites W2059646315 @default.
- W2116144264 cites W2061436805 @default.
- W2116144264 cites W2062864603 @default.
- W2116144264 cites W2068932079 @default.
- W2116144264 cites W2071127132 @default.
- W2116144264 cites W2073607158 @default.
- W2116144264 cites W2077358692 @default.
- W2116144264 cites W2077534408 @default.
- W2116144264 cites W2080289814 @default.
- W2116144264 cites W2081370552 @default.
- W2116144264 cites W2083855520 @default.
- W2116144264 cites W2084903350 @default.
- W2116144264 cites W2090500745 @default.
- W2116144264 cites W2092496616 @default.
- W2116144264 cites W2095199744 @default.
- W2116144264 cites W2106424708 @default.
- W2116144264 cites W2115713486 @default.
- W2116144264 cites W2123269821 @default.
- W2116144264 cites W2125726418 @default.
- W2116144264 cites W2131829834 @default.
- W2116144264 cites W2134747766 @default.
- W2116144264 cites W2142131601 @default.
- W2116144264 cites W2154468984 @default.
- W2116144264 cites W2159872853 @default.
- W2116144264 cites W2161455727 @default.
- W2116144264 cites W2162634566 @default.
- W2116144264 cites W2261192513 @default.
- W2116144264 cites W2316088955 @default.
- W2116144264 cites W2408585090 @default.
- W2116144264 cites W4230034432 @default.
- W2116144264 doi "https://doi.org/10.1177/0333102414534083" @default.
- W2116144264 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24820887" @default.
- W2116144264 hasPublicationYear "2014" @default.
- W2116144264 type Work @default.
- W2116144264 sameAs 2116144264 @default.
- W2116144264 citedByCount "40" @default.
- W2116144264 countsByYear W21161442642015 @default.
- W2116144264 countsByYear W21161442642016 @default.
- W2116144264 countsByYear W21161442642017 @default.
- W2116144264 countsByYear W21161442642018 @default.
- W2116144264 countsByYear W21161442642019 @default.
- W2116144264 countsByYear W21161442642020 @default.
- W2116144264 countsByYear W21161442642021 @default.
- W2116144264 countsByYear W21161442642022 @default.
- W2116144264 countsByYear W21161442642023 @default.
- W2116144264 crossrefType "journal-article" @default.
- W2116144264 hasAuthorship W2116144264A5024712968 @default.