FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116161397> ?p ?o ?g. }

• W2116161397 abstract "Abstract Epstein-Barr virus (EBV)-associated post-transplant smooth muscle tumours (PTSMT), are rare complications following organ/stem cell transplantation. Despite the mainly benign behaviour of PTSMT, alternative therapies are needed for those patients with progressive tumours. In tumours not approachable by surgery or reduction of immunosuppression, the angiogenic microenvironment might be a potential target of therapy, an approach that is well utilised in other soft tissue neoplasms. In a previous study, we evaluated the expression of EBV-related genes and the microRNA profile in PTSMT, but so far the characteristics of angiogenesis in PTSMT are not known. Therefore, the aim of this study was to evaluate the expression pattern of angiogenesis-related genes in PTSMT, in order to identify potential target molecules for anti-angiogenic therapy. PTSMT (n = 5 tumours) were compared with uterine leiomyomas (n = 7). Analyses included real-time PCR of 45 angiogenesis-associated genes, immunohistochemistry (CD31, prostaglandin endoperoxide synthase 1/PTGS1) and assessment of tumour vascularisation by conventional histopathology. PTSMT showed similar or fewer vessels than leiomyomas. Of the genes under investigation, 23 were down-deregulated (pro-angiogenic and some anti-angiogenic factors) and five were up-regulated (e.g. PTGS1 which is expressed at very low levels in leiomyomas but moderately higher levels in PTSMT). In summary, no particular target molecule could be identified, because tumour angiogenesis in PTSMT is characterised by low levels of major pro-angiogenic factors and there is no prominent increase in tumour vascularisation. EBV can induce angiogenesis via its viral late membrane protein 1 (LMP1) but PTSMT frequently do not express LMP1, which could be an explanation why, despite EBV infection, PTSMT show no exaggerated tumour angiogenesis." @default.
• W2116161397 created "2016-06-24" @default.
• W2116161397 creator A5017942521 @default.
• W2116161397 creator A5040906131 @default.
• W2116161397 creator A5044665296 @default.
• W2116161397 creator A5055379084 @default.
• W2116161397 creator A5068639127 @default.
• W2116161397 creator A5076738418 @default.
• W2116161397 creator A5086531770 @default.
• W2116161397 date "2014-01-07" @default.
• W2116161397 modified "2023-10-12" @default.
• W2116161397 title "Tumour angiogenesis in Epstein-Barr virus-associated post-transplant smooth muscle tumours" @default.
• W2116161397 cites W1539840949 @default.
• W2116161397 cites W1545117158 @default.
• W2116161397 cites W1970377933 @default.
• W2116161397 cites W1983472162 @default.
• W2116161397 cites W1992053527 @default.
• W2116161397 cites W2001901063 @default.
• W2116161397 cites W2017497777 @default.
• W2116161397 cites W2026094380 @default.
• W2116161397 cites W2030541266 @default.
• W2116161397 cites W2033040557 @default.
• W2116161397 cites W2045115099 @default.
• W2116161397 cites W2050152766 @default.
• W2116161397 cites W2064213778 @default.
• W2116161397 cites W2089403275 @default.
• W2116161397 cites W2090017296 @default.
• W2116161397 cites W2095867755 @default.
• W2116161397 cites W2101776780 @default.
• W2116161397 cites W2116286448 @default.
• W2116161397 cites W2133322319 @default.
• W2116161397 cites W2137266390 @default.
• W2116161397 cites W2144971212 @default.
• W2116161397 cites W2154100403 @default.
• W2116161397 cites W2168357141 @default.
• W2116161397 cites W2317177258 @default.
• W2116161397 cites W63983557 @default.
• W2116161397 doi "https://doi.org/10.1186/2045-3329-4-1" @default.
• W2116161397 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3896710" @default.
• W2116161397 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24398114" @default.
• W2116161397 hasPublicationYear "2014" @default.
• W2116161397 type Work @default.
• W2116161397 sameAs 2116161397 @default.
• W2116161397 citedByCount "7" @default.
• W2116161397 countsByYear W21161613972014 @default.
• W2116161397 countsByYear W21161613972017 @default.
• W2116161397 countsByYear W21161613972018 @default.
• W2116161397 countsByYear W21161613972019 @default.
• W2116161397 countsByYear W21161613972020 @default.
• W2116161397 countsByYear W21161613972021 @default.
• W2116161397 countsByYear W21161613972022 @default.
• W2116161397 crossrefType "journal-article" @default.
• W2116161397 hasAuthorship W2116161397A5017942521 @default.
• W2116161397 hasAuthorship W2116161397A5040906131 @default.
• W2116161397 hasAuthorship W2116161397A5044665296 @default.
• W2116161397 hasAuthorship W2116161397A5055379084 @default.
• W2116161397 hasAuthorship W2116161397A5068639127 @default.
• W2116161397 hasAuthorship W2116161397A5076738418 @default.
• W2116161397 hasAuthorship W2116161397A5086531770 @default.
• W2116161397 hasBestOaLocation W21161613971 @default.
• W2116161397 hasConcept C126322002 @default.
• W2116161397 hasConcept C142724271 @default.
• W2116161397 hasConcept C203014093 @default.
• W2116161397 hasConcept C204232928 @default.
• W2116161397 hasConcept C2778271429 @default.
• W2116161397 hasConcept C2778939058 @default.
• W2116161397 hasConcept C2780252810 @default.
• W2116161397 hasConcept C2780394083 @default.
• W2116161397 hasConcept C2911091166 @default.
• W2116161397 hasConcept C502942594 @default.
• W2116161397 hasConcept C71924100 @default.
• W2116161397 hasConceptScore W2116161397C126322002 @default.
• W2116161397 hasConceptScore W2116161397C142724271 @default.
• W2116161397 hasConceptScore W2116161397C203014093 @default.
• W2116161397 hasConceptScore W2116161397C204232928 @default.
• W2116161397 hasConceptScore W2116161397C2778271429 @default.
• W2116161397 hasConceptScore W2116161397C2778939058 @default.
• W2116161397 hasConceptScore W2116161397C2780252810 @default.
• W2116161397 hasConceptScore W2116161397C2780394083 @default.
• W2116161397 hasConceptScore W2116161397C2911091166 @default.
• W2116161397 hasConceptScore W2116161397C502942594 @default.
• W2116161397 hasConceptScore W2116161397C71924100 @default.
• W2116161397 hasIssue "1" @default.
• W2116161397 hasLocation W21161613971 @default.
• W2116161397 hasLocation W21161613972 @default.
• W2116161397 hasLocation W21161613973 @default.
• W2116161397 hasLocation W21161613974 @default.
• W2116161397 hasOpenAccess W2116161397 @default.
• W2116161397 hasPrimaryLocation W21161613971 @default.
• W2116161397 hasRelatedWork W2033614003 @default.
• W2116161397 hasRelatedWork W2101276432 @default.
• W2116161397 hasRelatedWork W2108506474 @default.
• W2116161397 hasRelatedWork W2151106513 @default.
• W2116161397 hasRelatedWork W2161429506 @default.
• W2116161397 hasRelatedWork W2363305562 @default.
• W2116161397 hasRelatedWork W2920952915 @default.
• W2116161397 hasRelatedWork W3044426045 @default.
• W2116161397 hasRelatedWork W3145991372 @default.
• W2116161397 hasRelatedWork W4283009821 @default.
• W2116161397 hasVolume "4" @default.

• next