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- W2116182014 abstract "The Sleeping Beauty ( SB ) transposon mutagenesis system is a powerful tool that facilitates the discovery of mutations that accelerate tumorigenesis. In this study, we sought to identify mutations that cooperate with MYC , one of the most commonly dysregulated genes in human malignancy. We performed a forward genetic screen with a mouse model of MYC-induced liver cancer using SB-mediated mutagenesis. We sequenced insertions in 63 liver tumor nodules and identified at least 16 genes/loci that contribute to accelerated tumor development. RNAi-mediated knockdown in a liver progenitor cell line further validate three of these genes, Ncoa2/Src-2, Zfx, and Dtnb , as tumor suppressors in liver cancer. Moreover, deletion of Ncoa2/Src-2 in mice predisposes to diethylnitrosamine-induced liver tumorigenesis. These findings reveal genes and pathways that functionally restrain MYC-mediated liver tumorigenesis and therefore may provide targets for cancer therapy." @default.
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- W2116182014 date "2012-05-03" @default.
- W2116182014 modified "2023-09-27" @default.
- W2116182014 title "A <i>Sleeping Beauty</i> mutagenesis screen reveals a tumor suppressor role for <i>Ncoa2/Src-2</i> in liver cancer" @default.
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- W2116182014 doi "https://doi.org/10.1073/pnas.1115433109" @default.
- W2116182014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3361419" @default.
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