FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116228267> ?p ?o ?g. }

• W2116228267 endingPage "631" @default.
• W2116228267 startingPage "624" @default.
• W2116228267 abstract "We measured in vitro phenotypes of early Pseudomonas aeruginosa isolates from children with cystic fibrosis in an antibiotic eradication therapy trial. Isolates frequently exhibited phenotypes associated with chronic adaptation. Two phenotypes were correlated with failure to eradicate, representing promising candidate markers. Background. Pseudomonas aeruginosa is a key respiratory pathogen in people with cystic fibrosis (CF). Due to its association with lung disease progression, initial detection of P. aeruginosa in CF respiratory cultures usually results in antibiotic treatment with the goal of eradication. Pseudomonas aeruginosa exhibits many different phenotypes in vitro that could serve as useful prognostic markers, but the relative relationships between these phenotypes and failure to eradicate P. aeruginosa have not been well characterized. Methods. We measured 22 easily assayed in vitro phenotypes among the baseline P. aeruginosa isolates collected from 194 participants in the 18-month EPIC clinical trial, which assessed outcomes after antibiotic eradication therapy for newly identified P. aeruginosa. We then evaluated the associations between these baseline isolate phenotypes and subsequent outcomes during the trial, including failure to eradicate after antipseudomonal therapy, emergence of mucoidy, and occurrence of an exacerbation. Results. Baseline P. aeruginosa isolates frequently exhibited phenotypes thought to represent chronic adaptation, including mucoidy. Wrinkly colony surface and irregular colony edges were both associated with increased risk of eradication failure (hazard ratios [95% confidence intervals], 1.99 [1.03–3.83] and 2.14 [1.32–3.47], respectively). Phenotypes reflecting defective quorum sensing were significantly associated with subsequent mucoidy, but no phenotype was significantly associated with subsequent exacerbations during the trial. Conclusions. Pseudomonas aeruginosa phenotypes commonly considered to reflect chronic adaptation were observed frequently among isolates at early detection. We found that 2 easily assayed colony phenotypes were associated with failure to eradicate after antipseudomonal therapy, both of which have been previously associated with altered biofilm formation and defective quorum sensing." @default.
• W2116228267 created "2016-06-24" @default.
• W2116228267 creator A5003117391 @default.
• W2116228267 creator A5008375832 @default.
• W2116228267 creator A5010165629 @default.
• W2116228267 creator A5011238311 @default.
• W2116228267 creator A5011278928 @default.
• W2116228267 creator A5030147092 @default.
• W2116228267 creator A5031182112 @default.
• W2116228267 creator A5033623131 @default.
• W2116228267 creator A5039823308 @default.
• W2116228267 creator A5055221785 @default.
• W2116228267 creator A5062599923 @default.
• W2116228267 creator A5077615947 @default.
• W2116228267 creator A5078050470 @default.
• W2116228267 creator A5079322424 @default.
• W2116228267 creator A5089416072 @default.
• W2116228267 date "2014-05-26" @default.
• W2116228267 modified "2023-10-03" @default.
• W2116228267 title "Pseudomonas aeruginosa Phenotypes Associated With Eradication Failure in Children With Cystic Fibrosis" @default.
• W2116228267 cites W1607935844 @default.
• W2116228267 cites W1935621017 @default.
• W2116228267 cites W1971558827 @default.
• W2116228267 cites W1973382671 @default.
• W2116228267 cites W1979152503 @default.
• W2116228267 cites W1985035909 @default.
• W2116228267 cites W1987865402 @default.
• W2116228267 cites W1992444327 @default.
• W2116228267 cites W1996632302 @default.
• W2116228267 cites W2010440576 @default.
• W2116228267 cites W2034472211 @default.
• W2116228267 cites W2055857822 @default.
• W2116228267 cites W2062652176 @default.
• W2116228267 cites W2068148539 @default.
• W2116228267 cites W2068781163 @default.
• W2116228267 cites W2069717071 @default.
• W2116228267 cites W2080335548 @default.
• W2116228267 cites W2081634999 @default.
• W2116228267 cites W2091822552 @default.
• W2116228267 cites W2092505971 @default.
• W2116228267 cites W2096684565 @default.
• W2116228267 cites W2096779618 @default.
• W2116228267 cites W2100669918 @default.
• W2116228267 cites W2103884572 @default.
• W2116228267 cites W2108862719 @default.
• W2116228267 cites W2110549473 @default.
• W2116228267 cites W2117532917 @default.
• W2116228267 cites W2122923061 @default.
• W2116228267 cites W2123273294 @default.
• W2116228267 cites W2128547781 @default.
• W2116228267 cites W2142641193 @default.
• W2116228267 cites W2148054572 @default.
• W2116228267 cites W2153102800 @default.
• W2116228267 cites W2153931434 @default.
• W2116228267 cites W2154399253 @default.
• W2116228267 cites W2166779461 @default.
• W2116228267 cites W2171315493 @default.
• W2116228267 cites W4235252773 @default.
• W2116228267 doi "https://doi.org/10.1093/cid/ciu385" @default.
• W2116228267 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4148602" @default.
• W2116228267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24863401" @default.
• W2116228267 hasPublicationYear "2014" @default.
• W2116228267 type Work @default.
• W2116228267 sameAs 2116228267 @default.
• W2116228267 citedByCount "56" @default.
• W2116228267 countsByYear W21162282672015 @default.
• W2116228267 countsByYear W21162282672016 @default.
• W2116228267 countsByYear W21162282672017 @default.
• W2116228267 countsByYear W21162282672018 @default.
• W2116228267 countsByYear W21162282672019 @default.
• W2116228267 countsByYear W21162282672020 @default.
• W2116228267 countsByYear W21162282672021 @default.
• W2116228267 countsByYear W21162282672022 @default.
• W2116228267 countsByYear W21162282672023 @default.
• W2116228267 crossrefType "journal-article" @default.
• W2116228267 hasAuthorship W2116228267A5003117391 @default.
• W2116228267 hasAuthorship W2116228267A5008375832 @default.
• W2116228267 hasAuthorship W2116228267A5010165629 @default.
• W2116228267 hasAuthorship W2116228267A5011238311 @default.
• W2116228267 hasAuthorship W2116228267A5011278928 @default.
• W2116228267 hasAuthorship W2116228267A5030147092 @default.
• W2116228267 hasAuthorship W2116228267A5031182112 @default.
• W2116228267 hasAuthorship W2116228267A5033623131 @default.
• W2116228267 hasAuthorship W2116228267A5039823308 @default.
• W2116228267 hasAuthorship W2116228267A5055221785 @default.
• W2116228267 hasAuthorship W2116228267A5062599923 @default.
• W2116228267 hasAuthorship W2116228267A5077615947 @default.
• W2116228267 hasAuthorship W2116228267A5078050470 @default.
• W2116228267 hasAuthorship W2116228267A5079322424 @default.
• W2116228267 hasAuthorship W2116228267A5089416072 @default.
• W2116228267 hasBestOaLocation W21162282672 @default.
• W2116228267 hasConcept C104317684 @default.
• W2116228267 hasConcept C126322002 @default.
• W2116228267 hasConcept C127716648 @default.
• W2116228267 hasConcept C207103383 @default.
• W2116228267 hasConcept C2776938444 @default.
• W2116228267 hasConcept C2777014857 @default.
• W2116228267 hasConcept C2777637488 @default.

• next