FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116234307> ?p ?o ?g. }

• W2116234307 endingPage "124" @default.
• W2116234307 startingPage "115" @default.
• W2116234307 abstract "Recent work has identified missense mutations in calmodulin (CaM) that are associated with severe early-onset long-QT syndrome (LQTS), leading to the proposition that altered CaM function may contribute to the molecular etiology of this subset of LQTS. To date, however, no experimental evidence has established these mutations as directly causative of LQTS substrates, nor have the molecular targets of CaM mutants been identified. Here, therefore, we test whether expression of CaM mutants in adult guinea-pig ventricular myocytes (aGPVM) induces action-potential prolongation, and whether affiliated alterations in the Ca2+ regulation of L-type Ca2+ channels (LTCC) might contribute to such prolongation. In particular, we first overexpressed CaM mutants in aGPVMs, and observed both increased action potential duration (APD) and heightened Ca2+ transients. Next, we demonstrated that all LQTS CaM mutants have the potential to strongly suppress Ca2+/CaM-dependent inactivation (CDI) of LTCCs, whether channels were heterologously expressed in HEK293 cells, or present in native form within myocytes. This attenuation of CDI is predicted to promote action-potential prolongation and boost Ca2+ influx. Finally, we demonstrated how a small fraction of LQTS CaM mutants (as in heterozygous patients) would nonetheless suffice to substantially diminish CDI, and derange electrical and Ca2+ profiles. In all, these results highlight LTCCs as a molecular locus for understanding and treating CaM-related LQTS in this group of patients." @default.
• W2116234307 created "2016-06-24" @default.
• W2116234307 creator A5005955450 @default.
• W2116234307 creator A5006064421 @default.
• W2116234307 creator A5006303682 @default.
• W2116234307 creator A5013560175 @default.
• W2116234307 creator A5045137391 @default.
• W2116234307 creator A5087303937 @default.
• W2116234307 date "2014-09-01" @default.
• W2116234307 modified "2023-10-16" @default.
• W2116234307 title "Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca2+ currents and promote proarrhythmic behavior in ventricular myocytes" @default.
• W2116234307 cites W1483083087 @default.
• W2116234307 cites W1510439895 @default.
• W2116234307 cites W1628979938 @default.
• W2116234307 cites W1777610481 @default.
• W2116234307 cites W1900127377 @default.
• W2116234307 cites W1963552271 @default.
• W2116234307 cites W1967803454 @default.
• W2116234307 cites W1972880122 @default.
• W2116234307 cites W1973026563 @default.
• W2116234307 cites W1973037262 @default.
• W2116234307 cites W1973544501 @default.
• W2116234307 cites W1976584289 @default.
• W2116234307 cites W1979881112 @default.
• W2116234307 cites W1995946312 @default.
• W2116234307 cites W2001594716 @default.
• W2116234307 cites W2012542028 @default.
• W2116234307 cites W2012544852 @default.
• W2116234307 cites W2013785072 @default.
• W2116234307 cites W2015593651 @default.
• W2116234307 cites W2017348510 @default.
• W2116234307 cites W2019028325 @default.
• W2116234307 cites W2022582268 @default.
• W2116234307 cites W2026404421 @default.
• W2116234307 cites W2027380922 @default.
• W2116234307 cites W2042443917 @default.
• W2116234307 cites W2045529347 @default.
• W2116234307 cites W2046197357 @default.
• W2116234307 cites W2048900664 @default.
• W2116234307 cites W2050867219 @default.
• W2116234307 cites W2052817643 @default.
• W2116234307 cites W2053330127 @default.
• W2116234307 cites W2057269307 @default.
• W2116234307 cites W2057785882 @default.
• W2116234307 cites W2078923802 @default.
• W2116234307 cites W2082438131 @default.
• W2116234307 cites W2084344997 @default.
• W2116234307 cites W2086871275 @default.
• W2116234307 cites W2087062865 @default.
• W2116234307 cites W2090486528 @default.
• W2116234307 cites W2093317479 @default.
• W2116234307 cites W2115812446 @default.
• W2116234307 cites W2130124702 @default.
• W2116234307 cites W2133398538 @default.
• W2116234307 cites W2133868014 @default.
• W2116234307 cites W2135227689 @default.
• W2116234307 cites W2138199557 @default.
• W2116234307 cites W2138773108 @default.
• W2116234307 cites W2139214355 @default.
• W2116234307 cites W2146357327 @default.
• W2116234307 cites W2160747375 @default.
• W2116234307 cites W2165970697 @default.
• W2116234307 cites W2166502047 @default.
• W2116234307 cites W2323663120 @default.
• W2116234307 cites W4294748274 @default.
• W2116234307 doi "https://doi.org/10.1016/j.yjmcc.2014.04.022" @default.
• W2116234307 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4262253" @default.
• W2116234307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24816216" @default.
• W2116234307 hasPublicationYear "2014" @default.
• W2116234307 type Work @default.
• W2116234307 sameAs 2116234307 @default.
• W2116234307 citedByCount "133" @default.
• W2116234307 countsByYear W21162343072014 @default.
• W2116234307 countsByYear W21162343072015 @default.
• W2116234307 countsByYear W21162343072016 @default.
• W2116234307 countsByYear W21162343072017 @default.
• W2116234307 countsByYear W21162343072018 @default.
• W2116234307 countsByYear W21162343072019 @default.
• W2116234307 countsByYear W21162343072020 @default.
• W2116234307 countsByYear W21162343072021 @default.
• W2116234307 countsByYear W21162343072022 @default.
• W2116234307 countsByYear W21162343072023 @default.
• W2116234307 crossrefType "journal-article" @default.
• W2116234307 hasAuthorship W2116234307A5005955450 @default.
• W2116234307 hasAuthorship W2116234307A5006064421 @default.
• W2116234307 hasAuthorship W2116234307A5006303682 @default.
• W2116234307 hasAuthorship W2116234307A5013560175 @default.
• W2116234307 hasAuthorship W2116234307A5045137391 @default.
• W2116234307 hasAuthorship W2116234307A5087303937 @default.
• W2116234307 hasBestOaLocation W21162343072 @default.
• W2116234307 hasConcept C104317684 @default.
• W2116234307 hasConcept C113217602 @default.
• W2116234307 hasConcept C118441451 @default.
• W2116234307 hasConcept C126322002 @default.
• W2116234307 hasConcept C134018914 @default.
• W2116234307 hasConcept C143065580 @default.
• W2116234307 hasConcept C146403970 @default.
• W2116234307 hasConcept C170493617 @default.

• next