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• W2116260324 endingPage "680" @default.
• W2116260324 startingPage "669" @default.
• W2116260324 abstract "Phenylephrine (PE) and metaraminol (MR) were studied alone at 2 × 10−5 m and at 4 × 10−5 m respectively. These drugs were also used both in the presence of either propranolol (PR) at 4 × 10−7 m ( groups) or prazosin (PZ) at 2 × 10−7 m ( groups). Specific α-adrenergic stimulation (AS) was induced in the and groups. These AS were evaluated in isotonic and isometric conditions on rat left ventricular papillary muscle. Peak shortening velocity (Vcmax) and peak lengthening velocity (Vrmax) were calculated from the twitch with preload only. Positive () and negative () peak derivative forces were calculated from the isometric twitch. Two coefficients R1 and R2 were used to measure the coupling between contraction and relaxation at low and heavy load, respectively: and . In all groups, there was a significant positive inotropic effect. As compared to control values before AS, R1 significantly decreased in all groups, (: −15%; : −18%; : −8%; : −23%; PE: −19%; MR: −32%). On the other hand, R2 significantly decreased only in three groups (: −5.4%; : −16.5%; MR: −12.0%) whereas it did not significantly change in the three other groups (; ; PE). In all groups, and at low load, Vrmax increased more than Vcmax (positive relaxant effect i.e. R1 decreased). At heavy load, despite the positive inotropic effect, there was no significant relaxant effect after predominent α-AS. These results indicate that α-AS modified the coupling between contraction and relaxation differently, depending on the level of load." @default.
• W2116260324 created "2016-06-24" @default.
• W2116260324 creator A5051176970 @default.
• W2116260324 creator A5069874881 @default.
• W2116260324 creator A5079794318 @default.
• W2116260324 creator A5063737413 @default.
• W2116260324 date "1989-07-01" @default.
• W2116260324 modified "2023-09-24" @default.
• W2116260324 title "Lusitropic effect and modifications of contraction-relaxation coupling induced by α-adrenergic stimulation in rat left ventricular papillary muscle" @default.
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• W2116260324 doi "https://doi.org/10.1016/0022-2828(89)90608-1" @default.
• W2116260324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2571734" @default.
• W2116260324 hasPublicationYear "1989" @default.
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