Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116262835> ?p ?o ?g. }
- W2116262835 endingPage "198" @default.
- W2116262835 startingPage "185" @default.
- W2116262835 abstract "AbstractThe inflammation produced by subplantar injection of sodium urate micro-crystals in the hindpaw of the rat was used as a model of gouty arthritis. Kinins are probably involved since carboxypeptidase B or soybean trypsin inhibitor partially (35%) blocked the edema. Serotonin does not participate since the edema was not prevented by methysergide or cyproheptadine. Histamine is apparently involved since many antihistaminics also partially (40%) suppressed this edema. Two antihistaminics, promethazine and tri-pelennamine, inhibited (75%) the edema as effectively as colchicine by mechanisms as yet not established. Treatment of rats with a combination of soybean trypsin inhibitor and a specific antihistaminic, triprolidine, inhibited the urate edema by 58-66%, which suggested that still another mediator was involved. Complement depletion of the rats also partially (30%) inhibited the edema. The combination of soybean trypsin inhibitor, triprolidine and complement depletion almost completely (80%) suppressed the edema. In the rat, therefore, urate edema appears to be mediated by the combined actions of kinins, histamine and the components of complement." @default.
- W2116262835 created "2016-06-24" @default.
- W2116262835 creator A5013456593 @default.
- W2116262835 creator A5038931299 @default.
- W2116262835 creator A5046689484 @default.
- W2116262835 creator A5067078630 @default.
- W2116262835 creator A5087753618 @default.
- W2116262835 date "1972-01-01" @default.
- W2116262835 modified "2023-10-04" @default.
- W2116262835 title "Urate Crystal Induced Inflammation in the Rat: Evidence for the Combined Actions of Kinins, Histamine and Components of Complement" @default.
- W2116262835 cites W1964899349 @default.
- W2116262835 cites W1998750935 @default.
- W2116262835 cites W2012757283 @default.
- W2116262835 cites W2030146622 @default.
- W2116262835 cites W2059246026 @default.
- W2116262835 cites W2059991147 @default.
- W2116262835 cites W2060419618 @default.
- W2116262835 cites W2081462859 @default.
- W2116262835 cites W2097584864 @default.
- W2116262835 cites W2117343102 @default.
- W2116262835 cites W2167902990 @default.
- W2116262835 cites W2325720070 @default.
- W2116262835 cites W2342156499 @default.
- W2116262835 cites W2418114720 @default.
- W2116262835 cites W2603461932 @default.
- W2116262835 cites W4238876088 @default.
- W2116262835 cites W4313308945 @default.
- W2116262835 cites W783917857 @default.
- W2116262835 cites W799863009 @default.
- W2116262835 cites W964224671 @default.
- W2116262835 doi "https://doi.org/10.3109/08820137209022934" @default.
- W2116262835 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4663514" @default.
- W2116262835 hasPublicationYear "1972" @default.
- W2116262835 type Work @default.
- W2116262835 sameAs 2116262835 @default.
- W2116262835 citedByCount "36" @default.
- W2116262835 countsByYear W21162628352012 @default.
- W2116262835 crossrefType "journal-article" @default.
- W2116262835 hasAuthorship W2116262835A5013456593 @default.
- W2116262835 hasAuthorship W2116262835A5038931299 @default.
- W2116262835 hasAuthorship W2116262835A5046689484 @default.
- W2116262835 hasAuthorship W2116262835A5067078630 @default.
- W2116262835 hasAuthorship W2116262835A5087753618 @default.
- W2116262835 hasConcept C1122143 @default.
- W2116262835 hasConcept C126322002 @default.
- W2116262835 hasConcept C134018914 @default.
- W2116262835 hasConcept C141814087 @default.
- W2116262835 hasConcept C170493617 @default.
- W2116262835 hasConcept C181199279 @default.
- W2116262835 hasConcept C185592680 @default.
- W2116262835 hasConcept C2775864247 @default.
- W2116262835 hasConcept C2776636253 @default.
- W2116262835 hasConcept C2776914184 @default.
- W2116262835 hasConcept C2778206117 @default.
- W2116262835 hasConcept C2779591629 @default.
- W2116262835 hasConcept C2780340462 @default.
- W2116262835 hasConcept C2780402116 @default.
- W2116262835 hasConcept C2780886150 @default.
- W2116262835 hasConcept C2781005078 @default.
- W2116262835 hasConcept C55493867 @default.
- W2116262835 hasConcept C71924100 @default.
- W2116262835 hasConcept C98274493 @default.
- W2116262835 hasConceptScore W2116262835C1122143 @default.
- W2116262835 hasConceptScore W2116262835C126322002 @default.
- W2116262835 hasConceptScore W2116262835C134018914 @default.
- W2116262835 hasConceptScore W2116262835C141814087 @default.
- W2116262835 hasConceptScore W2116262835C170493617 @default.
- W2116262835 hasConceptScore W2116262835C181199279 @default.
- W2116262835 hasConceptScore W2116262835C185592680 @default.
- W2116262835 hasConceptScore W2116262835C2775864247 @default.
- W2116262835 hasConceptScore W2116262835C2776636253 @default.
- W2116262835 hasConceptScore W2116262835C2776914184 @default.
- W2116262835 hasConceptScore W2116262835C2778206117 @default.
- W2116262835 hasConceptScore W2116262835C2779591629 @default.
- W2116262835 hasConceptScore W2116262835C2780340462 @default.
- W2116262835 hasConceptScore W2116262835C2780402116 @default.
- W2116262835 hasConceptScore W2116262835C2780886150 @default.
- W2116262835 hasConceptScore W2116262835C2781005078 @default.
- W2116262835 hasConceptScore W2116262835C55493867 @default.
- W2116262835 hasConceptScore W2116262835C71924100 @default.
- W2116262835 hasConceptScore W2116262835C98274493 @default.
- W2116262835 hasIssue "2" @default.
- W2116262835 hasLocation W21162628351 @default.
- W2116262835 hasLocation W21162628352 @default.
- W2116262835 hasOpenAccess W2116262835 @default.
- W2116262835 hasPrimaryLocation W21162628351 @default.
- W2116262835 hasRelatedWork W1989836890 @default.
- W2116262835 hasRelatedWork W2007858758 @default.
- W2116262835 hasRelatedWork W2027411819 @default.
- W2116262835 hasRelatedWork W2070001251 @default.
- W2116262835 hasRelatedWork W2073751688 @default.
- W2116262835 hasRelatedWork W2081245175 @default.
- W2116262835 hasRelatedWork W2096146683 @default.
- W2116262835 hasRelatedWork W2107899720 @default.
- W2116262835 hasRelatedWork W2212802410 @default.
- W2116262835 hasRelatedWork W4241062279 @default.
- W2116262835 hasVolume "1" @default.
- W2116262835 isParatext "false" @default.