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• W2116267756 abstract "ABSTRACT Cyclic di-GMP (c-di-GMP) is a second messenger that regulates diverse cellular processes in bacteria, including motility, biofilm formation, cell-cell signaling, and host colonization. Studies of c-di-GMP signaling have chiefly focused on Gram-negative bacteria. Here, we investigated c-di-GMP signaling in the Gram-positive bacterium Bacillus subtilis by constructing deletion mutations in genes predicted to be involved in the synthesis, breakdown, or response to the second messenger. We found that a putative c-di-GMP-degrading phosphodiesterase, YuxH, and a putative c-di-GMP receptor, YpfA, had strong influences on motility and that these effects depended on sequences similar to canonical EAL and RxxxR—D/NxSxxG motifs, respectively. Evidence indicates that YpfA inhibits motility by interacting with the flagellar motor protein MotA and that yuxH is under the negative control of the master regulator Spo0A∼P. Based on these findings, we propose that YpfA inhibits motility in response to rising levels of c-di-GMP during entry into stationary phase due to the downregulation of yuxH by Spo0A∼P. We also present evidence that YpfA has a mild influence on biofilm formation. In toto , our results demonstrate the existence of a functional c-di-GMP signaling system in B. subtilis that directly inhibits motility and directly or indirectly influences biofilm formation." @default.
• W2116267756 created "2016-06-24" @default.
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• W2116267756 date "2012-07-20" @default.
• W2116267756 modified "2023-10-18" @default.
• W2116267756 title "Evidence for Cyclic Di-GMP-Mediated Signaling in Bacillus subtilis" @default.
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• W2116267756 doi "https://doi.org/10.1128/jb.01092-12" @default.
• W2116267756 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3430322" @default.
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