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- W2116276246 abstract "The purpose of this study was to investigate whether or not clobenpropit, a selective and potent histamine H3 receptor antagonist, can protect from pentylenetetrazole (35 mg/kg)-kindled seizures in rats. I.c.v. injection with clobenpropit (10 and 20 μg) significantly delayed the seizure stage and prolonged the latency to the onset of myoclonic jerks and the latency to the clonic generalized seizure in a dose-dependent manner. The protection by clobenpropit (20 μg) was completely antagonized by both immepip (5 and 10 μg, i.c.v.), a selective potent histamine H3 receptor agonist, and α-fluoromethylhistidine (α-FMH, 50 μg, i.c.v.), a selective histidine decarboxylase inhibitor. In addition, clobenpropit markedly potentiated the histidine (100 and 200 mg/kg)-induced inhibition of pentylenetetrazole-kindled seizures. Pyrilamine (2 and 5 μg, i.c.v.) reversed the inhibition of pentylenetetrazole-kindled seizures induced by clobenpropit, whereas cimetidine had no effect even at a high dose of 5 μg. These results indicate that clobenpropit protects against pentylenetetrazole-kindled seizures in rats, and that its action is mainly due to the activation of endogenous histamine by blocking autoinhibitory presynaptic histamine H3 receptors." @default.
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- W2116276246 date "2003-12-15" @default.
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- W2116276246 title "Effects of clobenpropit on pentylenetetrazole-kindled seizures in rats" @default.
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- W2116276246 doi "https://doi.org/10.1016/j.ejphar.2003.09.066" @default.
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