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- W2116278557 abstract "To investigate the influence of a mineralocorticoid and a glucocorticoid on plasma immunoreactive atrial natriuretic peptide (irANP) and possible functional correlates, eight normal men received in random order 9α-fludrocortisone acetate (9αF; 0.6 mg/day), prednisone (50 mg/day), and placebo each for 9 days. Their diet contained 130 mmol sodium and 75 mmol potassium daily. The mean supine plasma irANP levels were similar on days 2, 4, and 9 of placebo treatment [25 ± 10 (±se), 27 ± 5, and 27 ± 6 pmol/L, respectively]. Mean plasma irANP levels were 76 ± 42 (P < 0.05), 89 ± 34, and 93 ± 29 pmol/L (P < 0.01), respectively, on days 2, 4, and 9 during 9αF administration, and 68 ± 37 (P < 0.05), 83 ± 41, and 48 ± 18 pmol/L on the same days during prednisone administration. Compared with the placebo period, sodium intake minus urinary output during 9αF administration averaged +41 mmol at the time of blood sampling on day 2, +112 mmol on day 4, and +149 mmol on day 9; body weight was unchanged on day 2 and increased by 0.7 and 1.1 kg on days 4 and 9, respectively. Escape from 9αF-induced renal sodium retention occurred on days 5 and 6. During prednisone administration, sodium intake minus urinary output and body weight did not change. Plasma volume and BP rose significantly during 9αF (P < 0.05) but not during prednisone administration. Plasma renin, aldosterone, and norepinephrine (NE) decreased during 9αF treatment (P < 0.05 to < 0.01); during prednisone treatment, plasma aldosterone levels were lower on day 9 only. Cardiovascular pressor responsiveness to angiotensin II was enhanced during 9αF but not prednisone administration, while blood pressure reactivity to NE was not significantly modified. These findings demonstrate that 9αF and prednisone in high doses provoke remarkably similar increases in plasma irANP, but that the glucocorticoid-induced rise in plasma irANP is due to a mechanism other than sodium and volume retention." @default.
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- W2116278557 date "1988-06-01" @default.
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- W2116278557 title "Glucocorticoid and Mineralocorticoid Stimulation of Atrial Natriuretic Peptide Release in Man*" @default.
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- W2116278557 doi "https://doi.org/10.1210/jcem-66-6-1233" @default.
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