FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116295153> ?p ?o ?g. }

• W2116295153 endingPage "734" @default.
• W2116295153 startingPage "724" @default.
• W2116295153 abstract "Subchronic treatment with memantine using osmotic pumps in male rats was used to verify whether plasma levels significantly blocking L-N-methyl-D-aspartate (NMDA) receptors (and shown previously to be neuroprotective) may impair learning. Treatment with 6.27, 12.5 and 18.8 mg/rat/day provided plasma levels of 1.03±0.08, 5.07±0.68 and 11.68±0.90 μmol/l. Only the lowest plasma level is therapeutically relevant and has previously been shown to be neuroprotective. Significant deficits in a passive avoidance task were only observed at the highest dose. Working memory, tested as spontaneous alternation in the cross maze, was impaired by the middle and highest doses, and these doses also induced hyperlocomotion. Microdialysis experiments with in-vivo recovery (27.4%) showed that infusion of memantine at 6.27 mg/rat/day (ca. 23 mg/kg/day) produced a concentration of 990±105 nmol/l in extracellular fluid. In-vivo NMDA receptor occupancy experiments demonstrated significant, dose-dependent receptor occupancy of 32.7 and 65.7% by memantine at the doses producing 1 and 5 μmol/l plasma levels, respectively. Moreover, acute administration (2.5 mg/kg intraperitoneally) of memantine to mature female rats produced approximately two-fold higher plasma levels than in young male rats. In conclusion, a dose of memantine which produces a plasma level (1 μmol/l) within the therapeutic range, reported previously to be neuroprotective, leads to intracellular brain levels similar to the affinity of memantine for NMDA receptors (receptor binding, patch clamp). This has been also extended by the experiments showing that at this plasma concentration, memantine occupies ca. 30% NMDA receptors in the brain and produces no cognitive impairment." @default.
• W2116295153 created "2016-06-24" @default.
• W2116295153 creator A5017981641 @default.
• W2116295153 creator A5040308925 @default.
• W2116295153 creator A5050176324 @default.
• W2116295153 creator A5060706996 @default.
• W2116295153 creator A5076782555 @default.
• W2116295153 creator A5089349685 @default.
• W2116295153 date "2008-10-01" @default.
• W2116295153 modified "2023-10-16" @default.
• W2116295153 title "Therapeutically relevant plasma concentrations of memantine produce significant L-N-methyl-D-aspartate receptor occupation and do not impair learning in rats" @default.
• W2116295153 cites W1974898218 @default.
• W2116295153 cites W1981383949 @default.
• W2116295153 cites W1989726412 @default.
• W2116295153 cites W1997568797 @default.
• W2116295153 cites W2002827758 @default.
• W2116295153 cites W2003437576 @default.
• W2116295153 cites W2003439867 @default.
• W2116295153 cites W2006299239 @default.
• W2116295153 cites W2013010178 @default.
• W2116295153 cites W2016584147 @default.
• W2116295153 cites W2016595675 @default.
• W2116295153 cites W2023243943 @default.
• W2116295153 cites W2023811880 @default.
• W2116295153 cites W2025996583 @default.
• W2116295153 cites W2032734645 @default.
• W2116295153 cites W2034383806 @default.
• W2116295153 cites W2040310848 @default.
• W2116295153 cites W2043358271 @default.
• W2116295153 cites W2043509263 @default.
• W2116295153 cites W2044546810 @default.
• W2116295153 cites W2044752122 @default.
• W2116295153 cites W2045369118 @default.
• W2116295153 cites W2048805575 @default.
• W2116295153 cites W2060707796 @default.
• W2116295153 cites W2063933455 @default.
• W2116295153 cites W2064577051 @default.
• W2116295153 cites W2078526156 @default.
• W2116295153 cites W2079901792 @default.
• W2116295153 cites W2082249282 @default.
• W2116295153 cites W2092356280 @default.
• W2116295153 cites W2093651696 @default.
• W2116295153 cites W2093755310 @default.
• W2116295153 cites W2094313222 @default.
• W2116295153 cites W2095277677 @default.
• W2116295153 cites W2099158542 @default.
• W2116295153 cites W2114163624 @default.
• W2116295153 cites W2117396078 @default.
• W2116295153 cites W2130826999 @default.
• W2116295153 cites W2132806643 @default.
• W2116295153 cites W2139654564 @default.
• W2116295153 cites W2143307990 @default.
• W2116295153 cites W2163401269 @default.
• W2116295153 cites W2170085655 @default.
• W2116295153 cites W243385979 @default.
• W2116295153 doi "https://doi.org/10.1097/fbp.0b013e3283123cad" @default.
• W2116295153 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18797249" @default.
• W2116295153 hasPublicationYear "2008" @default.
• W2116295153 type Work @default.
• W2116295153 sameAs 2116295153 @default.
• W2116295153 citedByCount "28" @default.
• W2116295153 countsByYear W21162951532012 @default.
• W2116295153 countsByYear W21162951532013 @default.
• W2116295153 countsByYear W21162951532014 @default.
• W2116295153 countsByYear W21162951532015 @default.
• W2116295153 countsByYear W21162951532016 @default.
• W2116295153 countsByYear W21162951532018 @default.
• W2116295153 countsByYear W21162951532019 @default.
• W2116295153 countsByYear W21162951532021 @default.
• W2116295153 countsByYear W21162951532022 @default.
• W2116295153 countsByYear W21162951532023 @default.
• W2116295153 crossrefType "journal-article" @default.
• W2116295153 hasAuthorship W2116295153A5017981641 @default.
• W2116295153 hasAuthorship W2116295153A5040308925 @default.
• W2116295153 hasAuthorship W2116295153A5050176324 @default.
• W2116295153 hasAuthorship W2116295153A5060706996 @default.
• W2116295153 hasAuthorship W2116295153A5076782555 @default.
• W2116295153 hasAuthorship W2116295153A5089349685 @default.
• W2116295153 hasConcept C126322002 @default.
• W2116295153 hasConcept C134018914 @default.
• W2116295153 hasConcept C150903083 @default.
• W2116295153 hasConcept C170493617 @default.
• W2116295153 hasConcept C185592680 @default.
• W2116295153 hasConcept C207001950 @default.
• W2116295153 hasConcept C25498285 @default.
• W2116295153 hasConcept C2779484449 @default.
• W2116295153 hasConcept C28406088 @default.
• W2116295153 hasConcept C50156730 @default.
• W2116295153 hasConcept C55493867 @default.
• W2116295153 hasConcept C61174792 @default.
• W2116295153 hasConcept C67018056 @default.
• W2116295153 hasConcept C71924100 @default.
• W2116295153 hasConcept C86803240 @default.
• W2116295153 hasConcept C98274493 @default.
• W2116295153 hasConceptScore W2116295153C126322002 @default.
• W2116295153 hasConceptScore W2116295153C134018914 @default.
• W2116295153 hasConceptScore W2116295153C150903083 @default.
• W2116295153 hasConceptScore W2116295153C170493617 @default.

• next