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- W2116300664 abstract "Seven of 8 patients with hypogammaglobulinemia and gastrointestinal symptoms were infected with Giardia lamblia. This parasite was not detected by multiple stool examinations in 4 of the 7 infected patients but was diagnosed correctly by small intestinal biopsy. Abnormalities of the small intestinal mucosa were found in all 8 patients. Two patients had nodular lymphoid hyperplasia and 3 the flat lesion of hypogammaglobulinemic sprue. The remaining 3 patients had mixed lesions; that is, the lesions varied both in severity of the villus abnormality and in the frequency of lymphoid nodules. All patients lacked plasma cells in the lamina propria. Because of the variation in the severity of the small intestinal abnormalities within individual patients, multiple small bowel biopsies were needed to evaluate the effects of treatment on mucosal morphology. After eradication of Giardia lamblia in 7 patients, the abnormalities in villus structure returned towards normal in all. No change occurred after a course of metronidazole (Flagyl) in the 1 patient who had a severe intestinal lesion but no evidence of giardiasis. Four patients with steatorrhea and giardiasis gained weight and their fecal fat excretion returned to normal. Diarrhea disappeared after treatment in the remaining 3 patients." @default.
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- W2116300664 date "1972-02-01" @default.
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- W2116300664 title "Relation of Giardiasis to Abnormal Intestinal Structure and Function in Gastrointestinal Immunodeficiency Syndromes" @default.
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- W2116300664 doi "https://doi.org/10.1016/s0016-5085(72)80172-0" @default.
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