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- W2116335958 abstract "Background: It has become clear in the recent years that predictive biomarkers are becoming an integral part of successful clinical management. Further, a lack of clear biomarkers has created a real challenge in licensing biodefense therapeutics and vaccines. The study presented seeks to develop tools for the discovery of new microRNA (miRNA) biomarkers for infectious diseases using advanced computational tools coupled with high density microarrays and animal test facilities to find novel miRNA markers of viral infection. The system is expected to be of utility to diagnostics and vaccine and therapeutics development. Methods: Extant software developed for miRNA sequence mining coupled with supercomputers has been used to analyze the genomes of human, mouse, rhesus macaque, and all full-length viral genomes available to identify candidate miRNAs that may be of utility for detecting viral infections and other perturbances of normal metabolic function. These sequences are being incorporated into high density microarrays that will be used to assess miRNA expression responses from humans, rhesus macaques, and mice for any infectious agent. Initial tests will be conducted on healthy tissue and tissue infected with filoviruses to determine miRNA responses specific to filovirus infection. This system can also be used for any other viral infection as well as other metabolic disturbances not necessarily related to viral infection and for biomarker discovery related to therapeutics and vaccine efficacy testing. The research proposed also aims to apply, for the first time, an miRNA screening tool to discovery of miRNA biomarkers for filovirus infection. Results: We have thus far identified 20442 viral pre-miRNA sequences, and 124292, 90054, and 104037 pre-miRNA sequences for humans, macaque, and mouse, respectively. Conclusion: Given our preliminary results, we are confident that our experiments seeking to validate these predicted miRNAs will yield novel markers of infection. Abstracts for SupplementInternational Journal of Infectious DiseasesVol. 14Preview Full-Text PDF Open Archive" @default.
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- W2116335958 date "2010-03-01" @default.
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- W2116335958 title "Identification of novel microRNA biomarkers of viral infection" @default.
- W2116335958 doi "https://doi.org/10.1016/j.ijid.2010.02.431" @default.
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