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- W2116338406 abstract "It is now commonly agreed that the human genome is not the stable entity originally presumed. Deletions, duplications, inversions, and insertions are common, and contribute significantly to genomic structural variations (SVs). Their collective impact generates much of the inter-individual genomic diversity observed among humans. Not only do these variations change the structure of the genome; they may also have functional implications, e.g. altered gene expression. Some SVs have been identified as the cause of genetic disorders, including cancer predisposition. Cancer cells are notorious for their genomic instability, and often show genomic rearrangements at the microscopic and submicroscopic level to which transposable elements (TEs) contribute. Here, we review the role of TEs in genome instability, with particular focus on non-LTR retrotransposons. Currently, three non-LTR retrotransposon families – long interspersed element 1 (L1), SVA (short interspersed element (SINE-R), variable number of tandem repeats (VNTR), and Alu), and Alu (a SINE) elements – mobilize in the human genome, and cause genomic instability through both insertion- and post-insertion-based mutagenesis. Due to the abundance and high sequence identity of TEs, they frequently mislead the homologous recombination repair pathway into non-allelic homologous recombination, causing deletions, duplications, and inversions. While less comprehensively studied, non-LTR retrotransposon insertions and TE-mediated rearrangements are probably more common in cancer cells than in healthy tissue. This may be at least partially attributed to the commonly seen global hypomethylation as well as general epigenetic dysfunction of cancer cells. Where possible, we provide examples that impact cancer predisposition and/or development." @default.
- W2116338406 created "2016-06-24" @default.
- W2116338406 creator A5005607145 @default.
- W2116338406 creator A5048181679 @default.
- W2116338406 date "2010-08-01" @default.
- W2116338406 modified "2023-10-17" @default.
- W2116338406 title "A mobile threat to genome stability: The impact of non-LTR retrotransposons upon the human genome" @default.
- W2116338406 cites W1503456964 @default.
- W2116338406 cites W1522566189 @default.
- W2116338406 cites W1535401771 @default.
- W2116338406 cites W163306480 @default.
- W2116338406 cites W1964013868 @default.
- W2116338406 cites W1965141089 @default.
- W2116338406 cites W1968939451 @default.
- W2116338406 cites W1969989752 @default.
- W2116338406 cites W1971570045 @default.
- W2116338406 cites W1973120052 @default.
- W2116338406 cites W1974115274 @default.
- W2116338406 cites W1978596306 @default.
- W2116338406 cites W1978669977 @default.
- W2116338406 cites W1981176106 @default.
- W2116338406 cites W1983640775 @default.
- W2116338406 cites W1984438480 @default.
- W2116338406 cites W1985575613 @default.
- W2116338406 cites W1986319478 @default.
- W2116338406 cites W1987332588 @default.
- W2116338406 cites W1988495745 @default.
- W2116338406 cites W1989068609 @default.
- W2116338406 cites W1990277130 @default.
- W2116338406 cites W1990381590 @default.
- W2116338406 cites W1990808653 @default.
- W2116338406 cites W1991493990 @default.
- W2116338406 cites W1996942642 @default.
- W2116338406 cites W1997697682 @default.
- W2116338406 cites W1999355295 @default.
- W2116338406 cites W1999884745 @default.
- W2116338406 cites W2001266010 @default.
- W2116338406 cites W2002190096 @default.
- W2116338406 cites W2004360438 @default.
- W2116338406 cites W2007202034 @default.
- W2116338406 cites W2007589425 @default.
- W2116338406 cites W2008257691 @default.
- W2116338406 cites W2008857432 @default.
- W2116338406 cites W2011016615 @default.
- W2116338406 cites W2012169926 @default.
- W2116338406 cites W2018780354 @default.
- W2116338406 cites W2020854816 @default.
- W2116338406 cites W2023865653 @default.
- W2116338406 cites W2028121819 @default.
- W2116338406 cites W2030496627 @default.
- W2116338406 cites W2032247293 @default.
- W2116338406 cites W2035511899 @default.
- W2116338406 cites W2036300762 @default.
- W2116338406 cites W2036994672 @default.
- W2116338406 cites W2037821015 @default.
- W2116338406 cites W2038288403 @default.
- W2116338406 cites W2039654451 @default.
- W2116338406 cites W2041152528 @default.
- W2116338406 cites W2041586254 @default.
- W2116338406 cites W2046471364 @default.
- W2116338406 cites W2050557699 @default.
- W2116338406 cites W2051216786 @default.
- W2116338406 cites W2051541780 @default.
- W2116338406 cites W2052937042 @default.
- W2116338406 cites W2053176287 @default.
- W2116338406 cites W2054143743 @default.
- W2116338406 cites W2054236386 @default.
- W2116338406 cites W2054890113 @default.
- W2116338406 cites W2055883194 @default.
- W2116338406 cites W2056375209 @default.
- W2116338406 cites W2058833396 @default.
- W2116338406 cites W2059173951 @default.
- W2116338406 cites W2060970186 @default.
- W2116338406 cites W2062093164 @default.
- W2116338406 cites W2065022250 @default.
- W2116338406 cites W2065045330 @default.
- W2116338406 cites W2066321170 @default.
- W2116338406 cites W2067668266 @default.
- W2116338406 cites W2071124171 @default.
- W2116338406 cites W2071422117 @default.
- W2116338406 cites W2074370703 @default.
- W2116338406 cites W2075168304 @default.
- W2116338406 cites W2075224242 @default.
- W2116338406 cites W2077053535 @default.
- W2116338406 cites W2077706025 @default.
- W2116338406 cites W2085151059 @default.
- W2116338406 cites W2086522028 @default.
- W2116338406 cites W2086739233 @default.
- W2116338406 cites W2087728031 @default.
- W2116338406 cites W2088207658 @default.
- W2116338406 cites W2089471275 @default.
- W2116338406 cites W2091279754 @default.
- W2116338406 cites W2091658544 @default.
- W2116338406 cites W2097502584 @default.
- W2116338406 cites W2102773855 @default.
- W2116338406 cites W2103973742 @default.
- W2116338406 cites W2106270511 @default.
- W2116338406 cites W2115759508 @default.