FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116338621> ?p ?o ?g. }

• W2116338621 abstract "Defects in skeletal muscle fatty acid oxidation have been implicated in the etiology of insulin resistance. Malonyl-CoA decarboxylase (MCD) has been a target of investigation because it reduces the concentration of malonyl-CoA, a metabolite that inhibits fatty acid oxidation. The in vivo role of muscle MCD expression in the development of insulin resistance remains unclear. To determine the role of MCD in skeletal muscle of diet induced obese and insulin resistant mouse models we generated mice expressing a muscle specific transgene for MCD (Tg-fMCDSkel) stabilized posttranslationally by the small molecule, Shield-1. Tg-fMCDSkel and control mice were placed on either a high fat or low fat diet for 3.5 months. Obese and glucose intolerant as well as lean control Tg-fMCDSkel and nontransgenic control mice were treated with Shield-1 and changes in their body weight and insulin sensitivity were determined upon induction of MCD. Inducing MCD activity >5-fold in skeletal muscle over two weeks did not alter body weight or glucose intolerance of obese mice. MCD induction further potentiated the defects in insulin signaling of obese mice. In addition, key enzymes in fatty acid oxidation were suppressed following MCD induction. Acute induction of MCD in the skeletal muscle of obese and glucose intolerant mice did not improve body weight and decreased insulin sensitivity compared to obese nontransgenic controls. Induction of MCD in skeletal muscle resulted in a suppression of mitochondrial oxidative genes suggesting a redundant and metabolite driven regulation of gene expression." @default.
• W2116338621 created "2016-06-24" @default.
• W2116338621 creator A5043042092 @default.
• W2116338621 creator A5051302586 @default.
• W2116338621 creator A5067816988 @default.
• W2116338621 date "2014-08-25" @default.
• W2116338621 modified "2023-10-14" @default.
• W2116338621 title "Chemical-genetic induction of Malonyl-CoA decarboxylase in skeletal muscle" @default.
• W2116338621 cites W1657478053 @default.
• W2116338621 cites W1966348307 @default.
• W2116338621 cites W1967384235 @default.
• W2116338621 cites W1971024458 @default.
• W2116338621 cites W1973842058 @default.
• W2116338621 cites W1978668631 @default.
• W2116338621 cites W1979315905 @default.
• W2116338621 cites W1981101682 @default.
• W2116338621 cites W1990152592 @default.
• W2116338621 cites W1990852009 @default.
• W2116338621 cites W1994437257 @default.
• W2116338621 cites W1995392322 @default.
• W2116338621 cites W1999697076 @default.
• W2116338621 cites W2002894227 @default.
• W2116338621 cites W2005033942 @default.
• W2116338621 cites W2007486805 @default.
• W2116338621 cites W2007527212 @default.
• W2116338621 cites W2013336262 @default.
• W2116338621 cites W2014671368 @default.
• W2116338621 cites W2030222351 @default.
• W2116338621 cites W2032264012 @default.
• W2116338621 cites W2036227669 @default.
• W2116338621 cites W2038881580 @default.
• W2116338621 cites W2039212784 @default.
• W2116338621 cites W2051970831 @default.
• W2116338621 cites W2062078854 @default.
• W2116338621 cites W2065034018 @default.
• W2116338621 cites W2067289453 @default.
• W2116338621 cites W2069095858 @default.
• W2116338621 cites W2070428551 @default.
• W2116338621 cites W2073168934 @default.
• W2116338621 cites W2073656642 @default.
• W2116338621 cites W2084320367 @default.
• W2116338621 cites W2086659315 @default.
• W2116338621 cites W2087770909 @default.
• W2116338621 cites W2092340120 @default.
• W2116338621 cites W2092441434 @default.
• W2116338621 cites W2095068198 @default.
• W2116338621 cites W2096269840 @default.
• W2116338621 cites W2098384661 @default.
• W2116338621 cites W2098822834 @default.
• W2116338621 cites W2099656577 @default.
• W2116338621 cites W2103180477 @default.
• W2116338621 cites W2105244824 @default.
• W2116338621 cites W2106693109 @default.
• W2116338621 cites W2109069233 @default.
• W2116338621 cites W2110542127 @default.
• W2116338621 cites W2114416343 @default.
• W2116338621 cites W2114437978 @default.
• W2116338621 cites W2120489134 @default.
• W2116338621 cites W2124833370 @default.
• W2116338621 cites W2129736201 @default.
• W2116338621 cites W2133094378 @default.
• W2116338621 cites W2134604231 @default.
• W2116338621 cites W2137842897 @default.
• W2116338621 cites W2138226825 @default.
• W2116338621 cites W2146528609 @default.
• W2116338621 cites W2150090192 @default.
• W2116338621 cites W2152386173 @default.
• W2116338621 cites W2154768987 @default.
• W2116338621 cites W2165604976 @default.
• W2116338621 cites W2165880135 @default.
• W2116338621 cites W2167497319 @default.
• W2116338621 cites W2169132538 @default.
• W2116338621 cites W2172039605 @default.
• W2116338621 cites W2785468108 @default.
• W2116338621 cites W4236897344 @default.
• W2116338621 doi "https://doi.org/10.1186/1471-2091-15-20" @default.
• W2116338621 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4236586" @default.
• W2116338621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25152047" @default.
• W2116338621 hasPublicationYear "2014" @default.
• W2116338621 type Work @default.
• W2116338621 sameAs 2116338621 @default.
• W2116338621 citedByCount "8" @default.
• W2116338621 countsByYear W21163386212016 @default.
• W2116338621 countsByYear W21163386212017 @default.
• W2116338621 countsByYear W21163386212019 @default.
• W2116338621 countsByYear W21163386212023 @default.
• W2116338621 crossrefType "journal-article" @default.
• W2116338621 hasAuthorship W2116338621A5043042092 @default.
• W2116338621 hasAuthorship W2116338621A5051302586 @default.
• W2116338621 hasAuthorship W2116338621A5067816988 @default.
• W2116338621 hasBestOaLocation W21163386211 @default.
• W2116338621 hasConcept C126322002 @default.
• W2116338621 hasConcept C134018914 @default.
• W2116338621 hasConcept C185592680 @default.
• W2116338621 hasConcept C2777391703 @default.
• W2116338621 hasConcept C2777477808 @default.
• W2116338621 hasConcept C2779306644 @default.
• W2116338621 hasConcept C2779959927 @default.
• W2116338621 hasConcept C62231903 @default.
• W2116338621 hasConcept C71924100 @default.

• next