Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116344367> ?p ?o ?g. }
- W2116344367 endingPage "9" @default.
- W2116344367 startingPage "5" @default.
- W2116344367 abstract "The 90 kDa ribosomal S6 kinase (RSK) family is a group of highly conserved Ser/Thr kinases that promote cell proliferation, growth, motility and survival. Deregulated RSK expression or activity has been associated with several human diseases, including cancer. RSK lies downstream of the Ras/mitogen-activated protein kinase (MAPK) signalling pathway and is directly phosphorylated by the extracellular signal-regulated kinases 1 and 2 (ERK1/2). Significant advances in the field of RSK signalling have occurred in the past few years, unravelling novel RSK cellular substrates and biological functions as well as new RSK regulatory mechanisms. Together, these findings suggest that RSK may be a promising therapeutic target for the treatment of cancer, particularly those characterized by oncogenic mutations in components of the Ras signalling pathway. This article briefly describes our current knowledge on the impact of RSK on cell growth and proliferation, as well as RSK-dependent mechanisms associated with tumourigenesis. The potential of targeting RSK in cancer is discussed in light of available data on the biological functions of each RSK family members. Targeting RSK with small molecule inhibitors appears to be a promising path for cancer therapy, but several considerations need to be evaluated and will be discussed in detail." @default.
- W2116344367 created "2016-06-24" @default.
- W2116344367 creator A5007113192 @default.
- W2116344367 creator A5059301202 @default.
- W2116344367 date "2010-10-19" @default.
- W2116344367 modified "2023-10-01" @default.
- W2116344367 title "Paving the way for targeting RSK in cancer" @default.
- W2116344367 cites W1908612571 @default.
- W2116344367 cites W1966939490 @default.
- W2116344367 cites W1970728706 @default.
- W2116344367 cites W1979456040 @default.
- W2116344367 cites W1982897400 @default.
- W2116344367 cites W1986730787 @default.
- W2116344367 cites W1991691204 @default.
- W2116344367 cites W1992746048 @default.
- W2116344367 cites W1993431258 @default.
- W2116344367 cites W1995496043 @default.
- W2116344367 cites W1998682097 @default.
- W2116344367 cites W1998809668 @default.
- W2116344367 cites W1999955117 @default.
- W2116344367 cites W2004583463 @default.
- W2116344367 cites W2010285972 @default.
- W2116344367 cites W2017549361 @default.
- W2116344367 cites W2022371765 @default.
- W2116344367 cites W2025457180 @default.
- W2116344367 cites W2036754434 @default.
- W2116344367 cites W2041308494 @default.
- W2116344367 cites W2042625441 @default.
- W2116344367 cites W2042830971 @default.
- W2116344367 cites W2046822015 @default.
- W2116344367 cites W2052615604 @default.
- W2116344367 cites W2052771249 @default.
- W2116344367 cites W2068652881 @default.
- W2116344367 cites W2070349030 @default.
- W2116344367 cites W2079948123 @default.
- W2116344367 cites W2106119346 @default.
- W2116344367 cites W2108958930 @default.
- W2116344367 cites W2110185475 @default.
- W2116344367 cites W2114869204 @default.
- W2116344367 cites W2124208429 @default.
- W2116344367 cites W2125666085 @default.
- W2116344367 cites W2134757689 @default.
- W2116344367 cites W2140117696 @default.
- W2116344367 cites W2143112776 @default.
- W2116344367 cites W2144654038 @default.
- W2116344367 cites W2150834226 @default.
- W2116344367 cites W2157761330 @default.
- W2116344367 cites W2160219683 @default.
- W2116344367 cites W2164180561 @default.
- W2116344367 cites W2165002727 @default.
- W2116344367 cites W2170665660 @default.
- W2116344367 cites W4249880655 @default.
- W2116344367 doi "https://doi.org/10.1517/14728222.2010.531014" @default.
- W2116344367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20958120" @default.
- W2116344367 hasPublicationYear "2010" @default.
- W2116344367 type Work @default.
- W2116344367 sameAs 2116344367 @default.
- W2116344367 citedByCount "52" @default.
- W2116344367 countsByYear W21163443672012 @default.
- W2116344367 countsByYear W21163443672013 @default.
- W2116344367 countsByYear W21163443672014 @default.
- W2116344367 countsByYear W21163443672015 @default.
- W2116344367 countsByYear W21163443672016 @default.
- W2116344367 countsByYear W21163443672017 @default.
- W2116344367 countsByYear W21163443672018 @default.
- W2116344367 countsByYear W21163443672019 @default.
- W2116344367 countsByYear W21163443672020 @default.
- W2116344367 countsByYear W21163443672021 @default.
- W2116344367 countsByYear W21163443672022 @default.
- W2116344367 countsByYear W21163443672023 @default.
- W2116344367 crossrefType "journal-article" @default.
- W2116344367 hasAuthorship W2116344367A5007113192 @default.
- W2116344367 hasAuthorship W2116344367A5059301202 @default.
- W2116344367 hasConcept C104202773 @default.
- W2116344367 hasConcept C11960822 @default.
- W2116344367 hasConcept C121608353 @default.
- W2116344367 hasConcept C184235292 @default.
- W2116344367 hasConcept C2780044377 @default.
- W2116344367 hasConcept C502942594 @default.
- W2116344367 hasConcept C51551487 @default.
- W2116344367 hasConcept C54355233 @default.
- W2116344367 hasConcept C55493867 @default.
- W2116344367 hasConcept C57074206 @default.
- W2116344367 hasConcept C58207958 @default.
- W2116344367 hasConcept C62112901 @default.
- W2116344367 hasConcept C62478195 @default.
- W2116344367 hasConcept C86554907 @default.
- W2116344367 hasConcept C86803240 @default.
- W2116344367 hasConcept C95444343 @default.
- W2116344367 hasConcept C96232424 @default.
- W2116344367 hasConcept C97029542 @default.
- W2116344367 hasConceptScore W2116344367C104202773 @default.
- W2116344367 hasConceptScore W2116344367C11960822 @default.
- W2116344367 hasConceptScore W2116344367C121608353 @default.
- W2116344367 hasConceptScore W2116344367C184235292 @default.
- W2116344367 hasConceptScore W2116344367C2780044377 @default.
- W2116344367 hasConceptScore W2116344367C502942594 @default.
- W2116344367 hasConceptScore W2116344367C51551487 @default.