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• W2116355383 abstract "Here, we present a new approach for protein ligand screening based on the use of limited exoproteolysis coupled to MALDI-TOF mass spectrometry, combined with computational modelling and prediction of binding energies. As a test for this combined approach, we have screened a combinatorial library containing 8000 peptides (organized in 60 peptide samples) based on positional scanning format. This library is attached to a poly-Pro framework, and screened against the Abl-SH3 domain. The results obtained demonstrated the validity of the experimental and theoretical approaches in identifying better ligands and in rationalizing the changes in affinity. Exoproteolysis coupled to MALDI-TOF mass spectrometry could be used to screen complex libraries in a fast and efficient way." @default.
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• W2116355383 date "2003-07-01" @default.
• W2116355383 modified "2023-09-26" @default.
• W2116355383 title "Ligand Screening by Exoproteolysis and Mass Spectrometry in Combination With Computer Modelling" @default.
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• W2116355383 doi "https://doi.org/10.1016/s0022-2836(03)00664-8" @default.
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