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• W2116362808 abstract "Pathways for EDTA-insensitive degradation of phosphatidylinositol (PI) were investigated in porcine platelet membranes and cytosol. The incubation of platelet membranes with [3H]glycerol-labeled PI in the presence of 2mM EDTA produced [3H]lysoPI and aqueous radioactive products, but not radioactive neutral lipids. The degradation in the membranes was optimal at pH8.0-9.0, while EDTA-insensitive hydrolysis was also observed in cytosol with optimal pH at pH7.0-9.0. The major water-soluble product was identified as glycerophosphoinositol. Under the conditions, [14C]arachidonate was released from 1-stearoyl-2-[14C]arachidonyl PI without accumulation of [14C]lysoPI. The deacylation activity preferred PI to phosphatidylcholine and phosphatidylethanolamine. Collectively, these results suggest that PI can be converted to lysoPI by phospholipase A2 in the absence of free Ca2+, providing the substrates for lysoPI-specific phospholipase C characterized earlier in porcine platelet membranes (Murase and Okuyama (1985) J.Biol.Chem. 260, 262-265)." @default.
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• W2116362808 date "1993-01-01" @default.
• W2116362808 modified "2023-10-17" @default.
• W2116362808 title "EDTA-insensitive deacylation of phosphatidylinositol in porcine platelet membranes" @default.
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• W2116362808 doi "https://doi.org/10.1016/0024-3205(93)90272-5" @default.
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