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• W2116367045 endingPage "261" @default.
• W2116367045 startingPage "254" @default.
• W2116367045 abstract "In both eukaryotes and prokaryotes, negative supercoiling of chromosomal DNA acts locally to regulate a variety of cellular processes, such as transcription, replication, recombination and response to environmental stresses. While studying the interaction between the Hin recombinase and mutated versions of its cognate DNA-binding site, we identified a mutated DNA site that binds Hin only when the DNA is supercoiled. To understand the mechanism of this supercoiling-responsive DNA site, we used NMR spectroscopy and fluorescence resonance energy transfer to determine the solution structures and dynamics of three related DNA oligonucleotides. The supercoiling-responsive DNA site formed a partially unwound and stretched helix and showed significant flexibility and base pair opening kinetics. The single CAG/CTG triplet contained in this DNA sequence displayed the same characteristics as do multiple CAG/CTG repeats, which are associated with several hereditary neuromuscular diseases. It is known that short DNA sequence motifs that have either very high or low bending flexibility occur preferentially at supercoiling-sensitive bacterial and eukaryotic promoters. From our results and these previous data, we propose a model in which supercoiling utilizes the intrinsic flexibility of a short DNA site to switch the local DNA structure from an inefficient conformation for protein binding to an efficient one, or vice versa." @default.
• W2116367045 created "2016-06-24" @default.
• W2116367045 creator A5072172310 @default.
• W2116367045 date "2006-01-08" @default.
• W2116367045 modified "2023-09-26" @default.
• W2116367045 title "Structural and dynamic basis of a supercoiling-responsive DNA element" @default.
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• W2116367045 doi "https://doi.org/10.1093/nar/gkj428" @default.
• W2116367045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1326020" @default.
• W2116367045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16414956" @default.
• W2116367045 hasPublicationYear "2006" @default.
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