Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116393881> ?p ?o ?g. }
- W2116393881 endingPage "1492" @default.
- W2116393881 startingPage "1479" @default.
- W2116393881 abstract "Twenty-five years ago the first small molecule inhibitors of Hsp90 were identified. In the intervening years there has been dramatic progress in basic scientific understanding of the Hsp90 chaperone machinery and in the role of Hsp90 in malignancy. The first-in-class Hsp90 inhibitor 17-AAG entered into Phase I clinical trials in 1999. There are now 13 Hsp90 inhibitors in clinical trial, representing multiple drug classes, and hundreds of patients have been treated in adult oncology and pediatric oncology trials. This review will provide an overview of the clinical trial results thus far. In addition, pivotal issues in further development of Hsp90 inhibitors as anticancer drugs will be discussed." @default.
- W2116393881 created "2016-06-24" @default.
- W2116393881 creator A5007047789 @default.
- W2116393881 creator A5009839679 @default.
- W2116393881 creator A5018089497 @default.
- W2116393881 creator A5022063365 @default.
- W2116393881 creator A5027567317 @default.
- W2116393881 creator A5040289016 @default.
- W2116393881 creator A5087156431 @default.
- W2116393881 date "2009-11-01" @default.
- W2116393881 modified "2023-09-26" @default.
- W2116393881 title "Update on Hsp90 Inhibitors in Clinical Trial" @default.
- W2116393881 cites W1559225535 @default.
- W2116393881 cites W1830803900 @default.
- W2116393881 cites W1953026682 @default.
- W2116393881 cites W1966373529 @default.
- W2116393881 cites W1970177198 @default.
- W2116393881 cites W1970700441 @default.
- W2116393881 cites W1976422747 @default.
- W2116393881 cites W1979202074 @default.
- W2116393881 cites W1987253577 @default.
- W2116393881 cites W199669094 @default.
- W2116393881 cites W1997113115 @default.
- W2116393881 cites W2006564825 @default.
- W2116393881 cites W2006880901 @default.
- W2116393881 cites W2019829775 @default.
- W2116393881 cites W2021780216 @default.
- W2116393881 cites W2025584298 @default.
- W2116393881 cites W2045843386 @default.
- W2116393881 cites W2047788533 @default.
- W2116393881 cites W2059524588 @default.
- W2116393881 cites W2064747304 @default.
- W2116393881 cites W2081704621 @default.
- W2116393881 cites W2082390299 @default.
- W2116393881 cites W2088942787 @default.
- W2116393881 cites W2090863165 @default.
- W2116393881 cites W2097490615 @default.
- W2116393881 cites W2098096093 @default.
- W2116393881 cites W2100092765 @default.
- W2116393881 cites W2100611890 @default.
- W2116393881 cites W2101550768 @default.
- W2116393881 cites W2108291133 @default.
- W2116393881 cites W2109635468 @default.
- W2116393881 cites W2112417555 @default.
- W2116393881 cites W2116725504 @default.
- W2116393881 cites W2123158115 @default.
- W2116393881 cites W2123476312 @default.
- W2116393881 cites W2124705172 @default.
- W2116393881 cites W2131384028 @default.
- W2116393881 cites W2139748674 @default.
- W2116393881 cites W2143329461 @default.
- W2116393881 cites W2144818233 @default.
- W2116393881 cites W2149246783 @default.
- W2116393881 cites W2155381255 @default.
- W2116393881 cites W2158341833 @default.
- W2116393881 cites W2158713870 @default.
- W2116393881 cites W2158780525 @default.
- W2116393881 cites W2163299200 @default.
- W2116393881 cites W2165918117 @default.
- W2116393881 doi "https://doi.org/10.2174/156802609789895728" @default.
- W2116393881 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7241864" @default.
- W2116393881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19860730" @default.
- W2116393881 hasPublicationYear "2009" @default.
- W2116393881 type Work @default.
- W2116393881 sameAs 2116393881 @default.
- W2116393881 citedByCount "258" @default.
- W2116393881 countsByYear W21163938812012 @default.
- W2116393881 countsByYear W21163938812013 @default.
- W2116393881 countsByYear W21163938812014 @default.
- W2116393881 countsByYear W21163938812015 @default.
- W2116393881 countsByYear W21163938812016 @default.
- W2116393881 countsByYear W21163938812017 @default.
- W2116393881 countsByYear W21163938812018 @default.
- W2116393881 countsByYear W21163938812019 @default.
- W2116393881 countsByYear W21163938812020 @default.
- W2116393881 countsByYear W21163938812021 @default.
- W2116393881 countsByYear W21163938812022 @default.
- W2116393881 countsByYear W21163938812023 @default.
- W2116393881 crossrefType "journal-article" @default.
- W2116393881 hasAuthorship W2116393881A5007047789 @default.
- W2116393881 hasAuthorship W2116393881A5009839679 @default.
- W2116393881 hasAuthorship W2116393881A5018089497 @default.
- W2116393881 hasAuthorship W2116393881A5022063365 @default.
- W2116393881 hasAuthorship W2116393881A5027567317 @default.
- W2116393881 hasAuthorship W2116393881A5040289016 @default.
- W2116393881 hasAuthorship W2116393881A5087156431 @default.
- W2116393881 hasBestOaLocation W21163938812 @default.
- W2116393881 hasConcept C104317684 @default.
- W2116393881 hasConcept C126322002 @default.
- W2116393881 hasConcept C143998085 @default.
- W2116393881 hasConcept C177713679 @default.
- W2116393881 hasConcept C197934379 @default.
- W2116393881 hasConcept C205260736 @default.
- W2116393881 hasConcept C2775932338 @default.
- W2116393881 hasConcept C2777560012 @default.
- W2116393881 hasConcept C2779399171 @default.
- W2116393881 hasConcept C2780035454 @default.
- W2116393881 hasConcept C535046627 @default.