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• W2116412507 abstract "Axonal degeneration is a major determinant of permanent neurological impairment during multiple sclerosis (MS). Due to the variable course of clinical disease and the heterogeneity of MS lesions, the mechanisms governing axonal degeneration may differ between disease stages. While the etiology of MS remains elusive, there now exist potential prognostic biomarkers that can predict the conversion to clinically definite MS. Specialized imaging techniques identifying axonal injury and drop-out are becoming established in clinical practice as a predictive measure of MS progression, such as optical coherence tomography (OCT) or diffusion tensor imaging (DTI). However, these imaging techniques are still being debated as predictive biomarkers since controversy surrounds their lesion-specific association with expanded disability status scale (EDSS). A more promising diagnostic measure of axonal degeneration has been argued for the detection of reduced N-acetyl aspartate (NAA) and Creatine ratios via magnetic resonance spectroscopic (MRS) imaging, but again fail with its specificity for predicting actual axonal degeneration. Greater accuracy of predictive biomarkers is therefore warranted and may include CSF neurofilament light chain (NF-L) and neurofilament heavy chain (NF-H) levels, for progressive MS. Furthermore, defining the molecular mechanisms that occur during the neurodegenerative changes in the various subgroups of MS may in fact prove vital for the future development of efficacious neuroprotective therapies. The clinical translation of a combined Na+ and Ca2+ channel blocker may lead to the establishment of a bona fide neuroprotective agent for the treatment of progressive MS. However, more specific therapeutic targets to limit axonal damage in MS need investigation and may include such integral axonal proteins such as the collapsin response mediator protein-2 (CRMP-2), a molecule which upon post-translational modification may propagate axonal degeneration in MS. In this review, we discuss the current clinical determinants of axonal damage in MS and consider the cellular and molecular mechanisms that may initiate these neurodegenerative changes. In particular we highlight the therapeutic candidates that may formulate novel therapeutic strategies to limit axonal degeneration and EDSS during progressive MS." @default.
• W2116412507 created "2016-06-24" @default.
• W2116412507 creator A5015937869 @default.
• W2116412507 creator A5021257318 @default.
• W2116412507 creator A5065923701 @default.
• W2116412507 date "2014-08-27" @default.
• W2116412507 modified "2023-10-16" @default.
• W2116412507 title "Axonal degeneration in multiple sclerosis: can we predict and prevent permanent disability?" @default.
• W2116412507 cites W1486755303 @default.
• W2116412507 cites W1521626316 @default.
• W2116412507 cites W1527204253 @default.
• W2116412507 cites W1577397450 @default.
• W2116412507 cites W1606137504 @default.
• W2116412507 cites W1895319737 @default.
• W2116412507 cites W1934231655 @default.
• W2116412507 cites W1963623842 @default.
• W2116412507 cites W1966571760 @default.
• W2116412507 cites W1971728959 @default.
• W2116412507 cites W1975921164 @default.
• W2116412507 cites W1976692470 @default.
• W2116412507 cites W1979548320 @default.
• W2116412507 cites W1980401964 @default.
• W2116412507 cites W1982441939 @default.
• W2116412507 cites W1983660498 @default.
• W2116412507 cites W1992144865 @default.
• W2116412507 cites W1992299091 @default.
• W2116412507 cites W1993921478 @default.
• W2116412507 cites W1994583461 @default.
• W2116412507 cites W1996000392 @default.
• W2116412507 cites W1998048194 @default.
• W2116412507 cites W2002108118 @default.
• W2116412507 cites W2003187874 @default.
• W2116412507 cites W2005536850 @default.
• W2116412507 cites W2005805156 @default.
• W2116412507 cites W2006178657 @default.
• W2116412507 cites W2006524711 @default.
• W2116412507 cites W2007291742 @default.
• W2116412507 cites W2008188679 @default.
• W2116412507 cites W2008356388 @default.
• W2116412507 cites W2011718960 @default.
• W2116412507 cites W2011888439 @default.
• W2116412507 cites W2012228419 @default.
• W2116412507 cites W2012932372 @default.
• W2116412507 cites W2013139068 @default.
• W2116412507 cites W2013948794 @default.
• W2116412507 cites W2016221456 @default.
• W2116412507 cites W2018899794 @default.
• W2116412507 cites W2020028069 @default.
• W2116412507 cites W2024521791 @default.
• W2116412507 cites W2024886848 @default.
• W2116412507 cites W2026101249 @default.
• W2116412507 cites W2026778635 @default.
• W2116412507 cites W2029997359 @default.
• W2116412507 cites W2030771734 @default.
• W2116412507 cites W2035847448 @default.
• W2116412507 cites W2036337813 @default.
• W2116412507 cites W2036836052 @default.
• W2116412507 cites W2038904444 @default.
• W2116412507 cites W2040331867 @default.
• W2116412507 cites W2042851493 @default.
• W2116412507 cites W2042991032 @default.
• W2116412507 cites W2044677981 @default.
• W2116412507 cites W2045724469 @default.
• W2116412507 cites W2048918000 @default.
• W2116412507 cites W2051274614 @default.
• W2116412507 cites W2052267680 @default.
• W2116412507 cites W2052881212 @default.
• W2116412507 cites W2052994550 @default.
• W2116412507 cites W2054236716 @default.
• W2116412507 cites W2055967330 @default.
• W2116412507 cites W2056030494 @default.
• W2116412507 cites W2056593502 @default.
• W2116412507 cites W2057243304 @default.
• W2116412507 cites W2058333671 @default.
• W2116412507 cites W2059830045 @default.
• W2116412507 cites W2063120457 @default.
• W2116412507 cites W2064286651 @default.
• W2116412507 cites W2068648104 @default.
• W2116412507 cites W2068772532 @default.
• W2116412507 cites W2069280713 @default.
• W2116412507 cites W2069725630 @default.
• W2116412507 cites W2070857423 @default.
• W2116412507 cites W2071151220 @default.
• W2116412507 cites W2071545791 @default.
• W2116412507 cites W2073222193 @default.
• W2116412507 cites W2075584671 @default.
• W2116412507 cites W2079076181 @default.
• W2116412507 cites W2079146964 @default.
• W2116412507 cites W2080428472 @default.
• W2116412507 cites W2081903103 @default.
• W2116412507 cites W2082250938 @default.
• W2116412507 cites W2082688434 @default.
• W2116412507 cites W2085105028 @default.
• W2116412507 cites W2085652779 @default.
• W2116412507 cites W2087609682 @default.
• W2116412507 cites W2087844435 @default.
• W2116412507 cites W2088779556 @default.
• W2116412507 cites W2089858611 @default.
• W2116412507 cites W2095999492 @default.
• W2116412507 cites W2096735314 @default.

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