FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116412941> ?p ?o ?g. }

• W2116412941 abstract "Abstract —Two subtypes of angiotensin II (Ang II) receptors, type 1 (AT 1 -R) and type 2 (AT 2 -R), have been identified in the heart. However, little is known about the regulation of cardiac AT 1 -R and AT 2 -R by Ang II in vivo. Thus, we examined cardiac AT 1 -R and AT 2 -R in angiotensinogen-deficient ( Atg-/- ) mice that are hypotensive and lack circulating Ang II. Cardiac Ang II receptors (Ang II-R) were assessed by radioligand binding with 125 I-[Sar 1 ,Ile 8 ]–Ang II in plasma membrane fractions. AT 1 -R and AT 2 -R were distinguished using their specific antagonists CV-11974 and PD123319 , respectively. Total densities of Ang II-R and AT 1 -R density were significantly greater in the Atg-/- mice than Atg+/+ mice (31.1±2.8 versus18.8±2.1, 28.7±3.0 versus16.9±2.3 fmol/mg protein, P <.01, respectively), and AT 2 -R showed a slight but not significant increase in Atg-/- mice relative to Atg+/+ control animals. K d values were not different between the two groups. In contrast to binding experiments, levels of Ang II type 1a receptor (AT 1a -R) and AT 2 -R mRNA did not differ between Atg-/- and Atg+/+ mice. These results suggest that lack of Ang II may upregulate AT 1 -R through translational and/or posttranslational mechanisms in Atg-/- mice." @default.
• W2116412941 created "2016-06-24" @default.
• W2116412941 creator A5001396238 @default.
• W2116412941 creator A5024713113 @default.
• W2116412941 creator A5025521503 @default.
• W2116412941 creator A5037235833 @default.
• W2116412941 creator A5039834644 @default.
• W2116412941 creator A5049659161 @default.
• W2116412941 creator A5051420763 @default.
• W2116412941 creator A5051960498 @default.
• W2116412941 creator A5061825004 @default.
• W2116412941 creator A5063566174 @default.
• W2116412941 creator A5063610442 @default.
• W2116412941 creator A5064332100 @default.
• W2116412941 creator A5075854659 @default.
• W2116412941 date "1998-01-01" @default.
• W2116412941 modified "2023-09-24" @default.
• W2116412941 title "Increased Cardiac Angiotensin II Receptors in Angiotensinogen-Deficient Mice" @default.
• W2116412941 cites W1518308338 @default.
• W2116412941 cites W1775749144 @default.
• W2116412941 cites W1821554906 @default.
• W2116412941 cites W1967561584 @default.
• W2116412941 cites W1967765607 @default.
• W2116412941 cites W1990257506 @default.
• W2116412941 cites W1997932090 @default.
• W2116412941 cites W2004327312 @default.
• W2116412941 cites W2006294557 @default.
• W2116412941 cites W2016342526 @default.
• W2116412941 cites W2017800047 @default.
• W2116412941 cites W2027850428 @default.
• W2116412941 cites W2055932468 @default.
• W2116412941 cites W2065236378 @default.
• W2116412941 cites W2072064327 @default.
• W2116412941 cites W2072625252 @default.
• W2116412941 cites W2082542825 @default.
• W2116412941 cites W2083868680 @default.
• W2116412941 cites W2092171289 @default.
• W2116412941 cites W2093548319 @default.
• W2116412941 cites W2095811222 @default.
• W2116412941 cites W2095911515 @default.
• W2116412941 cites W2110889457 @default.
• W2116412941 cites W2111175065 @default.
• W2116412941 cites W2125982887 @default.
• W2116412941 cites W2129277820 @default.
• W2116412941 cites W2129925176 @default.
• W2116412941 cites W2144757940 @default.
• W2116412941 cites W2172060077 @default.
• W2116412941 cites W2207566033 @default.
• W2116412941 cites W2412988869 @default.
• W2116412941 cites W4294216491 @default.
• W2116412941 doi "https://doi.org/10.1161/01.hyp.31.1.45" @default.
• W2116412941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9449389" @default.
• W2116412941 hasPublicationYear "1998" @default.
• W2116412941 type Work @default.
• W2116412941 sameAs 2116412941 @default.
• W2116412941 citedByCount "8" @default.
• W2116412941 countsByYear W21164129412013 @default.
• W2116412941 countsByYear W21164129412016 @default.
• W2116412941 crossrefType "journal-article" @default.
• W2116412941 hasAuthorship W2116412941A5001396238 @default.
• W2116412941 hasAuthorship W2116412941A5024713113 @default.
• W2116412941 hasAuthorship W2116412941A5025521503 @default.
• W2116412941 hasAuthorship W2116412941A5037235833 @default.
• W2116412941 hasAuthorship W2116412941A5039834644 @default.
• W2116412941 hasAuthorship W2116412941A5049659161 @default.
• W2116412941 hasAuthorship W2116412941A5051420763 @default.
• W2116412941 hasAuthorship W2116412941A5051960498 @default.
• W2116412941 hasAuthorship W2116412941A5061825004 @default.
• W2116412941 hasAuthorship W2116412941A5063566174 @default.
• W2116412941 hasAuthorship W2116412941A5063610442 @default.
• W2116412941 hasAuthorship W2116412941A5064332100 @default.
• W2116412941 hasAuthorship W2116412941A5075854659 @default.
• W2116412941 hasBestOaLocation W21164129411 @default.
• W2116412941 hasConcept C104317684 @default.
• W2116412941 hasConcept C104849204 @default.
• W2116412941 hasConcept C126322002 @default.
• W2116412941 hasConcept C127561419 @default.
• W2116412941 hasConcept C134018914 @default.
• W2116412941 hasConcept C150903083 @default.
• W2116412941 hasConcept C170493617 @default.
• W2116412941 hasConcept C185592680 @default.
• W2116412941 hasConcept C198710026 @default.
• W2116412941 hasConcept C207001950 @default.
• W2116412941 hasConcept C2908929049 @default.
• W2116412941 hasConcept C55493867 @default.
• W2116412941 hasConcept C67847695 @default.
• W2116412941 hasConcept C71924100 @default.
• W2116412941 hasConcept C84393581 @default.
• W2116412941 hasConcept C86803240 @default.
• W2116412941 hasConceptScore W2116412941C104317684 @default.
• W2116412941 hasConceptScore W2116412941C104849204 @default.
• W2116412941 hasConceptScore W2116412941C126322002 @default.
• W2116412941 hasConceptScore W2116412941C127561419 @default.
• W2116412941 hasConceptScore W2116412941C134018914 @default.
• W2116412941 hasConceptScore W2116412941C150903083 @default.
• W2116412941 hasConceptScore W2116412941C170493617 @default.
• W2116412941 hasConceptScore W2116412941C185592680 @default.
• W2116412941 hasConceptScore W2116412941C198710026 @default.
• W2116412941 hasConceptScore W2116412941C207001950 @default.
• W2116412941 hasConceptScore W2116412941C2908929049 @default.

• next