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- W2116413279 abstract "Although smoking rates in the UK are declining, by some measures nicotine is more addictive than alcohol, heroin and cocaine. Moreover, tobacco kills many more people than street drugs. This feature examines new research that offers unprecedented insights into the molecular and genetic basis of nicotine addiction. For instance, CNS nicotinic acetylcholine receptors (nAChRs) directly or indirectly influence numerous brain functions and pathways. To take one example, nAChRs modulate dopaminergic activity in pathways responsible for reward, memory and learning. Indeed, in many ways addiction arises from dysfunctional mental processes involved with learning. Partly as a result, nurses could consider tobacco dependence as a chronic disorder that requires repeated episodes of treatment. Genetic factors probably account for approximately 50% of the risk of nicotine dependence; they might also help to explain why only one-third of people who experiment with tobacco become regular smokers; and may influence the ef..." @default.
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- W2116413279 date "2012-02-01" @default.
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- W2116413279 title "Uncovering the basis of nicotine addiction" @default.
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- W2116413279 doi "https://doi.org/10.12968/npre.2012.10.2.80" @default.
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