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• W2116415854 abstract "Two of the main challenges that eukaryotic multicellular organisms faced during evolution were to eliminate and replace dying cells and to cope with invading microorganisms. The innate immune system evolved to handle both tasks: to scavenge cellular debris and to form the first line of defence against microbes. In this review, we focus on high mobility group box 1 (HMGB1) protein as a common signal that alerts the innate immune system to excessive or deregulated cell death and to microbial invasion. HMGB1, which is well known nuclear protein, has revealed unexpected facets as an extracellular mediator. The role of HMGB1 as an endogenous molecule that facilitates immune responses and has an important role in tissue homeostasis and disease will be highlighted here. Two of the main challenges that eukaryotic multicellular organisms faced during evolution were to eliminate and replace dying cells and to cope with invading microorganisms. The innate immune system evolved to handle both tasks: to scavenge cellular debris and to form the first line of defence against microbes. In this review, we focus on high mobility group box 1 (HMGB1) protein as a common signal that alerts the innate immune system to excessive or deregulated cell death and to microbial invasion. HMGB1, which is well known nuclear protein, has revealed unexpected facets as an extracellular mediator. The role of HMGB1 as an endogenous molecule that facilitates immune responses and has an important role in tissue homeostasis and disease will be highlighted here." @default.
• W2116415854 created "2016-06-24" @default.
• W2116415854 creator A5006241351 @default.
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• W2116415854 creator A5047988727 @default.
• W2116415854 creator A5087520444 @default.
• W2116415854 date "2005-07-01" @default.
• W2116415854 modified "2023-10-11" @default.
• W2116415854 title "HMGB1: guiding immunity from within" @default.
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• W2116415854 doi "https://doi.org/10.1016/j.it.2005.04.009" @default.
• W2116415854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15978523" @default.
• W2116415854 hasPublicationYear "2005" @default.
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