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- W2116446114 abstract "Microsomal UDP-glucuronyl transferases (uridine-5′-diphosphate-glucuronate glucuronyl transferase, acceptor unspecific, EC 2.4.1.17) function in detoxification of a wide range of aglycons containing phenolic, alcoholic, carboxylic or amino acceptor groups through formation of water-soluble glucuronic acid derivatives. To localize this activity within a specific cell component, purified rough-surfaced endoplasmic reticulum and Golgi apparatus fractions from rat liver were compared with total homogenates. The UDP-glucuronyl transferase specific activity of the Golgi apparatus fractions was less than or approximately equal to that of the total homogenate whereas this activity was concentrated 3–8 fold in the rough-surfaced endoplasmic reticulum fraction depending upon substrate. We conclude that the rough-surfaced endoplasmic reticulum is the major site of glucuronide formation within the microsome fraction of normal rat livers." @default.
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- W2116446114 date "1971-08-01" @default.
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- W2116446114 title "Distribution of UDP-glucuronyl transferase among cell fractions of rat liver" @default.
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- W2116446114 doi "https://doi.org/10.1002/jcp.1040780103" @default.
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