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• W2116446729 abstract "Renal prostaglandins (PC s ) might mediate an antihypertensive function of the kidney. The blood-superfused organ technique possesses the sensitivity (threshold < 0.4 ng/ml blood) and specificity required for identification of PGs in blood. Induction of unilateral renal ischemia in 14 chloraloseanesthetized dogs reduced renal blood flows from a mean value of 257 to 109 ml/min on the ischemic side and from 250 to 209 ml/min on the contralateral side. Concomitantly, PG-like substances were detected by assay organs in the venous blood of ischemic (13 experiments) and contralateral (11 experiments) kidneys. In one experiment, in a spontaneously hypertensive dog, PGs were not detected during renal ischemia. Renal venous blood and renal medullary tissue were extracted for acidic lipids and assayed for PG-like substances. Extracts of venous blood collected during renal ischemia and extracts of renal medulla yielded substances with biological activity indistinguishable from PG-like substances or PG standards. Chromatographic characterization of PG-like substances suggests that they are predominantly a mixture of PGE 2 and PGF 2α ." @default.
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• W2116446729 date "1970-11-01" @default.
• W2116446729 modified "2023-10-15" @default.
• W2116446729 title "Prostaglandin-Like Substances Appearing in Canine Renal Venous Blood During Renal Ischemia" @default.
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• W2116446729 doi "https://doi.org/10.1161/01.res.27.5.765" @default.
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