FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116446852> ?p ?o ?g. }

• W2116446852 endingPage "488" @default.
• W2116446852 startingPage "479" @default.
• W2116446852 abstract "Extragastrointestinal stromal tumor (EGIST) is a unique tumor that occurs outside the gastrointestinal tract. EGIST shows a c-kit expression and histologic appearance similar to those of gastrointestinal stromal tumor (GIST). Most GISTs have gain-of-functional mutation of the c-kit gene, and some have mutation of the platelet-derived growth factor receptor-alpha (PDGFRA) gene. However, the frequency of mutation of those genes in EGISTs remains unclear. We examined the clinicopathologic features, prognostic factors, and c-kit and PDGFRA mutation in 39 cases of EGIST. Tumors with high mitotic counts (≥5/50 high power fields) or a high Ki-67 labeling index (≥10%) were significantly correlated with worse prognoses. The c-kit mutation was found in the juxtamembrane domain (exon 11) and the extracellular domain (exon 9) in 12 of 29 cases (41.4%) and 2 of 29 cases (6.9%), respectively. The PDGFRA gene mutation was found at the juxtamembrane domain (exon 12) and the tyrosine kinase domain (exon 18) in one case each. The pattern of kit and PDGFRA mutation in EGIST was essentially similar to that in GIST. Our results suggest that the c-kit and PDGFRA mutations play an important role in the tumorigenesis of EGIST. High mitotic counts and a high Ki-67 labeling index may be useful for predicting the aggressive biologic behavior in EGIST. Furthermore, STI-571, targeting c-kit and PDGFR tyrosine kinase, seems to be a possible therapeutic strategy for EGISTs, especially advanced cases." @default.
• W2116446852 created "2016-06-24" @default.
• W2116446852 creator A5000104253 @default.
• W2116446852 creator A5007160336 @default.
• W2116446852 creator A5010476683 @default.
• W2116446852 creator A5016695290 @default.
• W2116446852 creator A5025082835 @default.
• W2116446852 creator A5040694302 @default.
• W2116446852 creator A5041401659 @default.
• W2116446852 creator A5049884976 @default.
• W2116446852 creator A5053242194 @default.
• W2116446852 creator A5083470582 @default.
• W2116446852 creator A5086305093 @default.
• W2116446852 date "2004-04-01" @default.
• W2116446852 modified "2023-09-23" @default.
• W2116446852 title "c-kit and PDGFRA Mutations in Extragastrointestinal Stromal Tumor (Gastrointestinal Stromal Tumor of the Soft Tissue)" @default.
• W2116446852 cites W1734860714 @default.
• W2116446852 cites W1971251991 @default.
• W2116446852 cites W1972284797 @default.
• W2116446852 cites W1983644799 @default.
• W2116446852 cites W2000998080 @default.
• W2116446852 cites W2003213723 @default.
• W2116446852 cites W2008920989 @default.
• W2116446852 cites W2020097092 @default.
• W2116446852 cites W2024702786 @default.
• W2116446852 cites W2028750359 @default.
• W2116446852 cites W2031242928 @default.
• W2116446852 cites W2033847195 @default.
• W2116446852 cites W2039037540 @default.
• W2116446852 cites W2057470956 @default.
• W2116446852 cites W2075994703 @default.
• W2116446852 cites W2077976050 @default.
• W2116446852 cites W2079420659 @default.
• W2116446852 cites W2101986793 @default.
• W2116446852 cites W2109508638 @default.
• W2116446852 cites W2113844763 @default.
• W2116446852 cites W2124541554 @default.
• W2116446852 cites W2132965295 @default.
• W2116446852 cites W2140626630 @default.
• W2116446852 cites W2171620774 @default.
• W2116446852 cites W2314511842 @default.
• W2116446852 cites W2321213005 @default.
• W2116446852 cites W2324850882 @default.
• W2116446852 cites W2329648702 @default.
• W2116446852 doi "https://doi.org/10.1097/00000478-200404000-00007" @default.
• W2116446852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15087667" @default.
• W2116446852 hasPublicationYear "2004" @default.
• W2116446852 type Work @default.
• W2116446852 sameAs 2116446852 @default.
• W2116446852 citedByCount "218" @default.
• W2116446852 countsByYear W21164468522012 @default.
• W2116446852 countsByYear W21164468522013 @default.
• W2116446852 countsByYear W21164468522014 @default.
• W2116446852 countsByYear W21164468522015 @default.
• W2116446852 countsByYear W21164468522016 @default.
• W2116446852 countsByYear W21164468522017 @default.
• W2116446852 countsByYear W21164468522018 @default.
• W2116446852 countsByYear W21164468522019 @default.
• W2116446852 countsByYear W21164468522020 @default.
• W2116446852 countsByYear W21164468522021 @default.
• W2116446852 countsByYear W21164468522022 @default.
• W2116446852 countsByYear W21164468522023 @default.
• W2116446852 crossrefType "journal-article" @default.
• W2116446852 hasAuthorship W2116446852A5000104253 @default.
• W2116446852 hasAuthorship W2116446852A5007160336 @default.
• W2116446852 hasAuthorship W2116446852A5010476683 @default.
• W2116446852 hasAuthorship W2116446852A5016695290 @default.
• W2116446852 hasAuthorship W2116446852A5025082835 @default.
• W2116446852 hasAuthorship W2116446852A5040694302 @default.
• W2116446852 hasAuthorship W2116446852A5041401659 @default.
• W2116446852 hasAuthorship W2116446852A5049884976 @default.
• W2116446852 hasAuthorship W2116446852A5053242194 @default.
• W2116446852 hasAuthorship W2116446852A5083470582 @default.
• W2116446852 hasAuthorship W2116446852A5086305093 @default.
• W2116446852 hasConcept C104317684 @default.
• W2116446852 hasConcept C109159458 @default.
• W2116446852 hasConcept C121608353 @default.
• W2116446852 hasConcept C142724271 @default.
• W2116446852 hasConcept C16930146 @default.
• W2116446852 hasConcept C170493617 @default.
• W2116446852 hasConcept C2022786 @default.
• W2116446852 hasConcept C2775922572 @default.
• W2116446852 hasConcept C2777007597 @default.
• W2116446852 hasConcept C28328180 @default.
• W2116446852 hasConcept C2910840531 @default.
• W2116446852 hasConcept C36823959 @default.
• W2116446852 hasConcept C37307934 @default.
• W2116446852 hasConcept C42362537 @default.
• W2116446852 hasConcept C501734568 @default.
• W2116446852 hasConcept C502942594 @default.
• W2116446852 hasConcept C54355233 @default.
• W2116446852 hasConcept C555283112 @default.
• W2116446852 hasConcept C71924100 @default.
• W2116446852 hasConcept C86803240 @default.
• W2116446852 hasConceptScore W2116446852C104317684 @default.
• W2116446852 hasConceptScore W2116446852C109159458 @default.
• W2116446852 hasConceptScore W2116446852C121608353 @default.
• W2116446852 hasConceptScore W2116446852C142724271 @default.

• next