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- W2116448148 abstract "Background: Panitumumab has a high affinity for epidermal growth factor receptor. Its utility as a salvage therapy is unknown in cetuximab-resistant colorectal cancer. We assessed the prognostic and predictive role of circulating tumor cells (CTCs) in KRAS wild-type metastatic Colorectal Cancer (mCRC) patients treated with panitumumab after progression on cetuximab.Methods: Panitumumab (6 mg/kg every 2 weeks) was administered as salvage therapy in a patient with cetuximab-resistant mCRC. The CTC count in whole blood at baseline was determined using immunomagnetics.Results: Nineteen patients were enrolled in the study between July 2010 and March 2011. Five patients had Stable Disease (SD) with a response rate of 0%. Four patients reached long-SD, which was defined as continuous SD of more than 120 days. All of these four patients had <2 CTCs. Multivariate analysis revealed that ≥2 CTCswas an independent predictor of Progression-Free Survival (PFS) (hazard ratio: 7.275, P=0.013). Patients with ≥2 CTCs had a shorter median PFS than those with <2 CTCs (1.8 versus 3.6 months, P=0.008). No statistically significant difference was observed in median overall survival between patients with ≥2 CTCs and those with <2 CTCs (3.2 versus 6.7 months, P=0.164). Conclusions: These results suggest that <2 CTCs indicates that panitumumab may be effective in patients with KRAS-wild-type mCRC after progression on cetuximab." @default.
- W2116448148 created "2016-06-24" @default.
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- W2116448148 date "2013-01-01" @default.
- W2116448148 modified "2023-09-26" @default.
- W2116448148 title "Circulating Tumor Cells as Prognostic Marker in Japanese patients with Kras Wild-type Metastatic Colorectal Cancer Receiving Panitumumab after Progression on Cetuximab" @default.
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- W2116448148 doi "https://doi.org/10.4172/2157-7099.1000204" @default.
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