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- W2116450823 abstract "In the developing embryo, cell-cell signalling is necessary for tissue patterning and structural organization. During midline development, the notochord plays roles in the patterning of its surrounding tissues while forming the axial structure; however, how these patterning and structural roles are coordinated remains elusive. Here, we identify a mechanism by which Notch signalling regulates the patterning activities and structural integrity of the notochord. We found that Mind bomb (Mib) ubiquitylates Jagged 1 (Jag1) and is essential in the signal-emitting cells for Jag1 to activate Notch signalling. In zebrafish, loss- and gain-of-function analyses showed that Mib-Jag1-Notch signalling favours the development of non-vacuolated cells at the expense of vacuolated cells in the notochord. This leads to changes in the peri-notochordal basement membrane formation and patterning surrounding the muscle pioneer cells. These data reveal a previously unrecognized mechanism regulating the patterning and structural roles of the notochord by Mib-Jag1-Notch signalling-mediated cell-fate determination." @default.
- W2116450823 created "2016-06-24" @default.
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- W2116450823 date "2010-08-01" @default.
- W2116450823 modified "2023-10-01" @default.
- W2116450823 title "Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions" @default.
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- W2116450823 doi "https://doi.org/10.1242/dev.051011" @default.
- W2116450823 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2927672" @default.
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